Evidence map›Paper›PMID 40518113›Full record

ArticleJournal of advanced research2026

Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment.

Minyi Zhang, Qi Wang, Chen Li, Mengyao Chen, Chunhui Wang, Zikang Wang, Tao Xia, Chengqing Yi, Shuo Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minyi ZhangSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China.
Qi WangDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Huinan Town, Pudong, Shanghai, PR China.
Chen LiSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China.
Mengyao ChenSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China.
Chunhui WangSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China.
Zikang WangSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China.
Tao XiaSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China.
Chengqing YiDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Huinan Town, Pudong, Shanghai, PR China. Electronic address: chengqing_yi@163.com.
Shuo ShiSchool of Chemical Science and Engineering, Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, PR China. Electronic address: shishuo@tongji.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIon interference therapy has emerged as a promising new treatment for Osteosarcoma (OS). However, its efficacy is significantly restricted by inadequate hydrogen peroxide (H

objectivesThis study aimed to supply sufficient H

methodsA hollow manganese dioxide (HMnO

resultsExcessive Ca

conclusionIn conclusion, HMnO

Indexed as

Bone NeoplasmsFerroptosisManganese CompoundsNanoparticlesOsteosarcomaOxidesPeroxidesAnimalsCalciumCell Line, TumorHumansHydrogen PeroxideMiceTumor MicroenvironmentCalciumcalcium peroxideHydrogen PeroxideManganese Compoundsmanganese dioxideOxidesPeroxidesCalcium overloadFerroptosisImmunotherapyIon interferenceReactive oxygen species

Identifiers

PMID40518113
PMCPMC12958199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.