Evidence map›Paper›PMID 40518051›Full record

ArticleAmerican journal of infection control2025

Outbreak of New Delhi metallo-β-lactamase carbapenemase-producing Pseudomonas aeruginosa infections in a Southern California hospital.

Jacob M Garrigues, Hannah K Gray, Ricardo P Ison, Daniel Z Uslan, Amorce Lima, Shekina Gonzalez-Ferrer, Marisol Trejo, Ran Zhuo, Colette J Matysiak Match, Erlinda R Ulloa and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Long-Term Environmental Surveillance ofPathogens (Basel, Switzerland) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jacob M GarriguesPublic Health Laboratories, County of Los Angeles Department of Public Health, Downey, CA.
Hannah K GrayDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Ricardo P IsonClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA.
Daniel Z UslanClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA.
Amorce LimaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Shekina Gonzalez-FerrerDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Marisol TrejoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Ran ZhuoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Colette J Matysiak MatchDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Erlinda R UlloaDivision of Infectious Diseases, Children's Hospital of Orange County, Orange, CA; Department of Pediatrics, University of California Irvine School of Medicine, Irvine, CA.
Sandeep BhaurlaAcute Communicable Disease Control, County of Los Angeles Department of Public Health, Los Angeles, CA.
Vanessa LewisClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA.
Urvashi PartiClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA.
Tessa SandovalClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA.
Sebora TurayClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA.
Shaunté WaltonClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA.
Kavitha PrabakerClinical Epidemiology & Infection Prevention, UCLA Health, Los Angeles, CA; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA.
Omai B GarnerDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Sukantha ChandrasekaranDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Nicole M GreenPublic Health Laboratories, County of Los Angeles Department of Public Health, Downey, CA. Electronic address: nicgreen@ph.lacounty.gov.
Shangxin YangDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA. Electronic address: shangxinyang@mednet.ucla.edu.

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
Beta-Lactamase Inhibitors Sensitize Multidrug-Resistant Gram-negative Pathogens to Innate Immune ClearanceK08AI151253 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ULLOA, ERLINDA ROSE · 2020 to 2024
$1.0M
NCATS NIH HHS UM1 TR004927NCEZID CDC HHS NU50CK000495NCEZID CDC HHS NU51CK000357NCEZID CDC HHS U01 CK000357NIAID NIH HHS K08 AI151253
6 · The paper itself

Abstract

backgroundCarbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) is a major public health threat due to limited treatment options and high transmissibility. Though widespread globally, few instances of locally transmitted New Delhi metallo-β-lactamase (NDM)-producing CP-CRPA have been documented in the United States. Here, a cluster of locally transmitted NDM-1 CP-CRPA infections in Southern California is reported.

methodsEpidemiologic investigations involving both patient screening and environmental surveillance by microbiological culture, carbapenemase testing, and bacterial whole-genome sequencing were conducted.

resultsThrough extensive epidemiologic investigations, a sink environmental reservoir was identified. A genetically unique strain of NDM-CRPA was identified to be transmitted among seven patients in a single hospital over the course of 1.5 years. Changes in antimicrobial resistance genes harbored by a mobile genetic element were identified between the index and later cases, and the gene encoding NDM-1 resided within a mobile genetic element on the chromosome displaying evidence of widespread transmission between different species. Several interventions were implemented, including sink P-trap replacement and disinfectant against Pseudomonas biofilms. No additional cases were identified after the interventions.

conclusionsImplementation of real-time pathogen surveillance enabled effective response to an ongoing outbreak that involved environmental sampling, microbiological testing, whole-genome sequencing, facility management, and updated infection prevention policies.

Indexed as

Bacterial Proteinsbeta-LactamasesCross InfectionDisease OutbreaksPseudomonas aeruginosaPseudomonas InfectionsAdultAgedAnti-Bacterial AgentsCaliforniaFemaleHospitalsHumansMaleMiddle AgedWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase NDM-1beta-LactamasescarbapenemaseGenomic surveillanceNDMP-trapSinkWhole-genome sequencing

Identifiers

PMID40518051
PMCPMC13464689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.