Evidence map›Paper›PMID 40517946›Full record

ReviewProgress in retinal and eye research2025

Widefield OCT angiography.

Yali Jia, Tristan T Hormel, Thomas S Hwang, An-Lun Wu, Guangru B Liang, Yukun Guo, Xiang Wei, Shuibin Ni, Yifan Jian, J Peter Campbell and 3 more

Erratum issuedAbstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Strip-Scanning for Efficient Widefield Retinal OCTA Mosaicking.Translational vision science & technology · 2026
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yali JiaCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA. Electronic address: jiaya@ohsu.edu.
Tristan T HormelCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Thomas S HwangCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
An-Lun WuCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Guangru B LiangCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Yukun GuoCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Xiang WeiCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Shuibin NiCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Yifan JianCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
J Peter CampbellCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Steven T BaileyCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
John C MorrisonCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
David HuangCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
STUDIES IN GLAUCOMATOUS OPTIC NERVE DAMAGER01EY010145 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, JOHN C · 1993 to 2023
$8.9M
Functional and Structural Optical Coherence Tomography for GlaucomaR01EY023285 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2013 to 2026
$8.8M
Clinical and Genetic Analysis of Retinopathy of PrematurityR01EY019474 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2010 to 2020
$7.0M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
OCTA Precursors of Vision-Threatening Complications of Diabetic RetinopathyR01EY035410 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Thomas Hwang, Yali Jia · 2023 to 2026
$2.5M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Advancing visible-light OCT in oxygen-induced retinopathyR01EY036429 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell, Yali Jia · 2024 to 2026
$2.0M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucomaR01EY031394 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, MORRISON, JOHN C · 2020 to 2022
$1.6M
Robust AI to develop risk models in retinopathy of prematurity using deep learningR21EY031883 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, RUBIN, DANIEL L · 2020 to 2021
$472k
NCATS NIH HHS UL1 TR002369NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY010145NEI NIH HHS R01 EY019474NEI NIH HHS R01 EY023285NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NEI NIH HHS R01 EY031331NEI NIH HHS R01 EY031394NEI NIH HHS R01 EY035410NEI NIH HHS R01 EY036429NEI NIH HHS R21 EY031883NEI NIH HHS R43 EY036781NEI NIH HHS T32 EY023211
6 · The paper itself

Abstract

Optical coherence tomography angiography (OCTA) is a volumetric, non-invasive, high-resolution vascular imaging modality capable of acquiring highly detailed visualizations of retinal microvasculature. It has become an important tool for diagnosis and prognosis in prevalent diseases and pathologies such as diabetic retinopathy, retinopathy of prematurity, and vein occlusions, as well as more rare conditions, including inherited retinal dystrophies. It is also useful for measuring treatment response and assessing which patients would benefit from treatment. Unlike dye-based angiography, OCTA eliminates risks such as anaphylaxis. It also often outperforms fundus photography in feature detection. However, conventional OCTA imaging has been limited by its small field of view, which restricts simultaneous visualization of the posterior pole and peripheral retina, causing single images to potentially miss widely spaced critical biomarkers and pathological features. Recent technological advances in widefield OCTA have addressed this limitation, extending the field of view to the mid-periphery and beyond. This breakthrough enhances the simultaneous detection of macular and peripheral retinal pathology and significantly broadens OCTA's diagnostic and research applications. This review explores the technical innovations enabling widefield OCTA and highlights its clinical utility across various conditions, emphasizing its growing importance as a powerful tool in ophthalmic practice and research.

Indexed as

Fluorescein AngiographyRetinal DiseasesRetinal VesselsTomography, Optical CoherenceHumansOCT angiographyRetinaWidefield imaging

Identifiers

PMID40517946
PMCPMC12342419

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.