ReviewCancer letters2025
Energetics of whole genome doubling and genomic instability.
Review in Cancer letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Whole genome doubling (WGD) is among the most prevalent genomic alterations in cancer, present in approximately one third of patients at the time of diagnosis. WGD provides cancer cells with a selective advantage, by protecting against mutations in haploinsufficient genes or buffering deleterious mutations. Factors which negatively select against the WGD state are largely unexplored. Here, we review evidence indicating that cells with WGD are more sensitive to resource restriction than their non-WGD counterparts. We hypothesize that differences in energy access across tissue sites explain differences in cancer ploidy and aneuploidy at the time of detection. By shedding light on the energetic constraints that influence cancer ploidy and aneuploidy, this perspective highlights a critical yet underexplored area of cancer research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.