Evidence map›Paper›PMID 40517384›Full record

ArticleCell reports2025

Modulation of motor excitability reflects traveling waves of neural oscillations.

Zachary J Haigh, Harry Tran, Taylor Berger, Sina Shirinpour, Ivan Alekseichuk, Seth Koenig, Jan Zimmermann, Robert McGovern, David Darrow, Alexander Herman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zachary J HaighDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Harry TranDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Taylor BergerDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Sina ShirinpourDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Ivan AlekseichukDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Seth KoenigDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Jan ZimmermannDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Robert McGovernDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
David DarrowDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Alexander HermanDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Miles WischnewskiDepartment of Behavioral and Social Sciences, University of Groningen, Groningen, the Netherlands.
Alexander OpitzDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. Electronic address: aopitz@umn.edu.

Funding

Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain NetworksRF1MH124909 · NIMH · UNIVERSITY OF MINNESOTA · PI OPITZ, ALEXANDER · 2020 to 2020
$2.4M
NIMH NIH HHS RF1 MH124909
6 · The paper itself

Abstract

Neural traveling waves represent an important endogenous phenomenon with structural and functional relevance in the human brain. These waves, commonly recorded via electroencephalogram (EEG) or electrocorticography (ECoG), are implicated in a range of brain processes. However, it remains unclear how they influence neural excitability across brain regions. Advancements in real-time control of brain stimulation present opportunities to compare traveling waves and excitation. Here, we investigate how sensorimotor mu (8-13 Hz) and beta (14-30 Hz) traveling waves affect motor cortex excitability using real-time EEG-controlled transcranial magnetic stimulation (TMS). We observed gradients in the mediolateral direction and then validated these findings using ECoG recordings in a human participant and a nonhuman primate. Our results demonstrate that neuronal excitability reflects the natural patterns of sensorimotor traveling waves. This provides important evidence of traveling waves modulating neural excitability in humans. This opens possibilities for more effective stimulation protocols aligned with intrinsic brain dynamics.

Indexed as

Motor CortexAdultAnimalsElectrocorticographyElectroencephalographyEvoked Potentials, MotorFemaleHumansMacaca mulattaMaleTranscranial Magnetic StimulationYoung Adultclosed-loopCP: Neuroscienceelectrocorticographyelectroencephalographymotor cortexreal-time stimulationTMS-EEGtranscranial magnetic stimulationtraveling waves

Identifiers

PMID40517384
PMCPMC12257788

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.