Evidence map›Paper›PMID 40517383›Full record

ArticleCell reports2025

The IL-33/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin.

Sophie Ward, Greg Crawford, Buang Norzawani, Christina Malactou, Emma Dutton, Isabella Withnell, Kevin J Woollard, Catherine Harwood, Henry J McSorley, Christoph Ziegenhain and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Elevated ST2Arthritis research & therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sophie WardDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Greg CrawfordDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Buang NorzawaniDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Christina MalactouDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Emma DuttonDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Isabella WithnellDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Kevin J WoollardDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Catherine HarwoodCentre for Cell Biology and Cutaneous Research, Queen Mary University of London, London, UK.
Henry J McSorleyDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Christoph ZiegenhainDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Adrian LärkerydCentre for Translational Immunotherapy, The Institute of Cancer Research, London, UK.
Anguraj SadanandamCentre for Translational Immunotherapy, The Institute of Cancer Research, London, UK; Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Jessica StridDepartment of Immunology and Inflammation, Imperial College London, London, UK. Electronic address: j.strid@imperial.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Interleukin (IL)-33 is constitutively expressed in many epithelial tissues at steady state and signals through the receptor, ST2. IL-33 is released upon tissue injury and functions as an endogenous danger signal to alert the immune system to tissue damage. Here we investigate the physiological role of the IL-33/ST2 axis in skin homeostasis and cancer development. We show that the expression of IL-33 differentiates malignant from normal and benign human tissues and that in mouse models of cutaneous squamous cell carcinoma the IL-33/ST2 axis protects against carcinogenesis. Tissue regulatory T cells (Tregs) are the predominant cells expressing ST2 in the skin and localize around the hair follicle and IL-33

Indexed as

Cell Transformation, NeoplasticHomeostasisInterleukin-1 Receptor-Like 1 ProteinInterleukin-33NeoplasmsSkinT-Lymphocytes, RegulatoryAnimalsEpithelial CellsFemaleLymphocyte ActivationMiceMice, KnockoutMutationIl1rl1 protein, mouseIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33cancerCP: CancerCP: ImmunologycSCCIL-33immune-surveillanceinflammationskinST2 receptorTregtype 2 immunity

Identifiers

PMID40517383
PMCPMC7619240

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.