ReviewBiochemistry2025
Dynamic Cytoplasm: A Physical Regulator of Enzymatic Function.
Review in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Developmentally programmed changes in cytoplasmic mechanics revealed by active microrheology inbioRxiv : the preprint server for biology · 2026Article
- Sperm mitochondrial sheath formation - how and why?Nature reviews. Urology · 2026Review
- Polarization as a Process: The Potential of Process Ontology for Understanding Cellular Symmetry Breaking.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Functional requirements of the liver isoform of phosphofructokinase-1 in breast cancer cell migration.Journal of cell science · 2025Article
- Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies.Chembiochem : a European journal of chemical biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytoplasm is a dynamic, self-organizing system spanning scales from organelles to biomolecular condensates and multienzyme assemblies. While enzymatic regulation has traditionally been attributed to transcriptional control and allostery, emerging evidence highlights the cytoplasm's physical properties─macromolecular crowding, viscosity, and diffusion─as a crucial yet underappreciated regulatory layer. These biophysical factors actively modulate enzymatic activity and metabolic flux, maintaining homeostasis and enabling adaptive cellular responses. This Perspective explores the biochemical interplay between the cytosolic environment and enzymatic function, emphasizing how cytoplasmic organization contributes to metabolic regulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.