Evidence map›Paper›PMID 40517247›Full record

ReviewVirology journal2025

Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity.

Yahya A Almutawif, Haydar M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Hamza M A Eid, Athanasios Alexiou, Marios Papadakis, Mohammed E Abo-El Fetoh, Gaber El-Saber Batiha

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yahya A AlmutawifDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi Arabia.ORCID 0000-0002-5654-6139
Haydar M Al-KuraishyDepartment of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Ali I Al-GareebJabir ibn Hayyan Medical University, Al-Ameer Qu./ Najaf, Po. Box (13), Kufa, Iraq.
Ali K AlbuhadilyDepartment of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Hamza M A EidDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi Arabia.ORCID 0000-0002-6215-5409
Athanasios AlexiouDepartment of Research & Development, Funogen, Athens, 11741, Attiki, Greece.ORCID 0000-0002-2206-7236
Marios PapadakisUniversity Hospital Witten-Herdecke, University of Witten-Herdecke, Heusnerstrasse 40, 42283, Wuppertal, Germany. drmariospapadakis@gmail.com.
Mohammed E Abo-El FetohDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, 11829, Badr City, Cairo, Egypt. mohamed-ezzat@eru.edu.eg.ORCID 0000-0002-5068-184X
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, 22511, Egypt. gaberbatiha@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the possible methods for MPXV infection to induce autoimmune responses and damage pancreatic β-cells. We examine from published articles the possible MPXV-induced immune dysregulation and inflammation in the development of T1D. Utilizing insights from other diabetogenic viruses, such as enterovirus and SARS-CoV-2. Currently, the association between MPXV and the development of T1D is scarce. Therefore, additional studies are essential for establishing a conclusive causal link between MPXV and T1D.

Indexed as

AutoimmunityDiabetes Mellitus, Type 1Insulin-Secreting CellsMonkeypox virusMpox, MonkeypoxAnimalsHumansInflammationSARS-CoV-2Signal TransductionAutoimmunityCOVID-19CytokinesDiabetogenic virusesImmune dysregulationInflammationMonkeypoxPancreatic β-cellsType 1 diabetesViral infections

Identifiers

PMID40517247
PMCPMC12166575

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.