ArticleCardiovascular diabetology2025
Association of atherogenic index of plasma and its modified indices with stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Depression and risk of incident heart diseases among older adults at CKM stages 0-3: evidence from the China Health and Retirement Longitudinal Study.Annals of medicine · 2026Article
- Associations of atherogenic index of plasma related indices with subclinical carotid atherosclerosis.Annals of medicine · 2026Article
- Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between the atherogenic index of plasma and prognosis in kidney transplant recipients: a retrospective cohort study.International urology and nephrology · 2026Article
- Association of non-conventional lipid-inflammatory parameters with incident hypertension risk: a prospective cohort study.Journal of global health · 2026Article
- Comparison of CTI and its modified indices in predicting cardiovascular disease risk across different glycemic statuses: a nationwide prospective cohort study.Diabetology & metabolic syndrome · 2026Article
- Association of C-reactive protein-triglyceride glucose index and its modified indices with stroke risk in individuals at cardiovascular-kidney-metabolic syndrome stages 0-3: a population-based cohort study.Cardiovascular diabetology · 2026Article
- Association of Frailty and Its Trajectories With the Risk of Cardiovascular-Kidney-Metabolic Syndrome Progression: A Longitudinal Cohort Study.Geriatrics & gerontology international · 2026Article
- Association of the atherogenic index of plasma and its integrative novel adiposity-based composites with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: novel adiposity-derived AIP indices provide modest incremental prognostic information.Cardiovascular diabetology · 2026Article
- Associations of the atherogenic index of plasma and its modified indices with the incidence and progression of cardiometabolic multimorbidity in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Association of the C-reactive protein-triglyceride-glucose (CTI) index and its central obesity-modified derivatives with incident cardiometabolic multimorbidity: results from two prospective cohorts in China and England.Cardiovascular diabetology · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the combined atherogenic and frailty index with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Article
- Associations between 12 insulin resistance surrogates with metabolic dysfunction-associated steatotic liver disease risk and all-cause mortality: data from the NHANES III (1988-1994).European journal of gastroenterology & hepatology · 2026Article
- Associations of the atherogenic index of plasma and its modified indices with the incidence and progression of cardiovascular-liver-metabolic multimorbidity: a prospective cohort study from UK Biobank.Cardiovascular diabetology · 2026Article
- Predictive value of cholesterol, high-density lipoprotein, and glucose index-obesity-derived index for stroke: a cohort study.Lipids in health and disease · 2026Article
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- Association of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose and its modified indices with cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2026Observational
- Association between adverse childhood experiences and cardiovascular disease risk in cardiovascular kidney metabolic syndrome stages 0 to 3.Scientific reports · 2026Article
- Cardiovascular-kidney-metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management.Cardiovascular diabetology · 2026Review
- Emerging multidimensional biomarker system for cardiovascular-kidney-metabolic syndrome: from multi-omics integration to clinical artificial intelligence.Cardiovascular diabetology · 2026Review
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Abstract
backgroundThe association between the atherogenic index of plasma (AIP), its modified indices (such as AIP-waist circumference [AIP-WC], AIP-waist-to-height ratio [AIP-WHtR], AIP-body mass index[AIP-BMI]), and incident stroke in individuals with cardiovascular-kidney-metabolic (CKM) stages 0-3 remains understudied. This study investigated these associations and their utility for risk stratification.
methodsData from 3697 China Health and Retirement Longitudinal Study (CHARLS) participants (≥ 45 years, CKM stages 0-3) were analyzed. Baseline, cumulative, and changes in AIP and its modified indices (AIP-WC, AIP-WHtR, AIP-BMI) were calculated. Logistic regression, Delong's test, integrated discrimination improvement (IDI), weighted quantile sum (WQS) regression, and mediation analysis were used to assess associations, predictive performance, component contributions, and mediation effects.
resultsStroke occurred in 4.8% of participants. Under the fully adjusted Model 3: The third level of AIP, AIP-WHtR, AIP-WC, and AIP-BMI showed increased risks (ORs 1.58 [95% CI 1.05-2.38], 1.99 [95% CI 1.31-3.02], 1.99 [95% CI 1.31-3.02], and 1.92 [95% CI 1.26-2.92], respectively); The third level of cumulative AIP, AIP-WHtR, AIP-WC, and AIP-BMI showed elevated risks (ORs 1.79 [95% CI 1.19-2.69], 2.07 [95% CI 1.37-3.13], 2.01 [95% CI 1.33-3.04], and 1.92 [95% CI 1.27-2.89], respectively); The third category of AIP, AIP-WHtR, AIP-WC, and AIP-BMI changes showed risk increases of 2.28 (95% CI 1.46-3.55), 2.39 (95% CI 1.50-3.79), 2.56 (95% CI 1.61-4.07), and 2.22 (95% CI 1.38-3.56). Modified AIP indices (especially AIP-WHtR) demonstrated superior predictive ability than AIP alone. The association was amplified in advanced CKM (stages 2-3) but not significant in early CKM (stages 0-1). Triglycerides (TG) primarily drove the AIP-WHtR-stroke risk, which was partially mediated by estimated pulse wave velocity (ePWV) (6.48%).
conclusionsAIP and its modified indices, especially AIP-WHtR, are significantly associated with incident stroke in CKM stages 0-3. Dynamically monitoring changes in these indices is crucial for stroke risk assessment and stratification, particularly in advanced CKM. TG primarily drives this risk, while ePWV partially mediates the AIP-WHtR-stroke link.
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