SynthesisOdontology2026
Potential of irrigants and medicaments in regenerative endodontics: insights from a systematic review on dentin growth factor release.
Synthesis in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study.BMC oral health · 2026Article
- Laser-induced modulation of root dentin surface for growth factor release and enhanced stem cell response.Lasers in medical science · 2026Article
- Effect of Adjunctive Ozone Application Protocols on Dentin-Derived Growth Factor Release: An In Vitro Study.Journal of clinical medicine · 2026Article
- Antimicrobial effectiveness of intracanal medicaments againstFrontiers in oral health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This study systematically reviews the literature on protocols used in regenerative endodontic procedures, focusing on the relationship between irrigants, intracanal medicaments, and the release of dentin-derived growth factors, which form one of the foundational pillars of regenerative endodontics. Systematic searches were conducted in PubMed, Web of Science, Scopus, Google Scholar, and gray literature for English studies (2015-2024). The included studies investigated growth factor release associated with irrigants or intracanal medicaments in human dentin. QUIN tool assessed methodological quality. Of the three-thousand-seven-hundred-and-seventy-four screened, seventeen studies were included in the review. Ethylenediaminetetraacetic acid (EDTA), either alone or combined with sodium hypochlorite (NaOCl) or chlorhexidine, and 10% citric acid were the most effective in releasing TGF-β1 and BMPs (BMP2 and BMP7). Although this systematic review demonstrates methodological heterogeneity among studies, there was a tendency for increased levels of TGF-β1 and BMP with the use of EDTA (10 or 17%) associated or not with NaOCl or chlorhexidine, while the release of VEGF and FGF2 was minimal or undetectable. Regarding the intracanal medicaments, the use of calcium hydroxide paste (Ca(OH)₂) paste demonstrated an increase in TGF-β1 release. However, this result should be interpreted with caution due to the limited number of available studies.
Indexed as
Identifiers
40517172What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.