ArticleNPJ science of food2025
Network pharmacology and UPLC/MS/MS metabolic profiling unveil the anti-inflammatory potential of Trifolium alexandrinum.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Chemometric insights into Lactiplantibacillus plantarum effects on onion (Allium cepa L.) metabolism and antidiabetic activity under cadmium stress.Scientific reports · 2026Article
- PTGS2-Based Network Pharmacology and Molecular Modeling Investigation of the Antioxidant Potential of EthanolicLife (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Trifolium alexandrinum, commonly known as berseem clover, has long been used in traditional medicine for its diverse therapeutic properties. In this study, we explore the anti-inflammatory potential of T. alexandrinum through an integrated approach combining network pharmacology and LC-MS/MS metabolic profiling. The ethanolic extract of T. alexandrinum was fractionated and analyzed, revealing a rich profile of phytoconstituents, including flavonoids, isoflavonoids, triterpenoid glycosides, and purine nucleosides. Network pharmacology analysis identified key bioactive compounds, such as tryptophan and adenosine, which exhibited strong interactions with inflammation-related genes, including TNF-α, IL-6, IL-1β, and INF-γ, as demonstrated from the "compound-target-pathway" constructed network. The arachidonic acid metabolism pathway, which plays a pivotal role in inflammation, was the top-listed pathway in the network. For the sake of confirmation, tryptophan and adenosine were isolated from the butanol fraction, and their structures were elucidated using
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Registered trials
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