ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
The changing profile of laryngeal cancer: a 20-year retrospective cohort analysis.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaryngeal cancer incidence has declined in the Western World, but subsite-specific trends are underreported. This study assessed changes in the profile of laryngeal cancer patients in a regional cancer network.
methodsTwo patient cohorts from the west of Scotland were analysed: 326 patients diagnosed in 1999-2001 (historical cohort) and 386 diagnosed in 2018-2020 (contemporary cohort). Changes in risk factors, tumour characteristics, and treatment patterns were compared using Chi-square and Student's t-tests. Two-year survival was assessed using the Kaplan-Meier method and Cox proportional hazards models.
resultsOverall proportion of supraglottic (C32.1) cancers increased from 38.0 to 58.0%, becoming the predominant subtype, while glottic (C32.0) cancers decreased from 56.7 to 32.6% (p < 0.001). Early-stage diagnosis of glottic cancers rose from 65.6 to 77.0% (p = 0.031), while supraglottic cancers continued present at advanced stages, 70.5% vs. 64.3% (p = 0.24). Surgical treatment for all laryngeal cancers increased from 10.4 to 38.2%, while radiotherapy declined from 57.7 to 38.2% (p < 0.001). Two-year risk of death for glottic cancers decreased by 42% in the contemporary cohort (p = 0.02), with no significant survival change for supraglottic or overall laryngeal cancers.
conclusionGlottic cancers now represent a smaller proportion of laryngeal cancer cases, with earlier diagnosis and improved survival outcomes. Conversely, supraglottic cancers have become more prevalent, often diagnosed at advanced stages without improvements in overall survival.
Indexed as
Identifiers
40517162What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.