ArticleBritish journal of cancer2025
Increased cancer risk in kidney transplant patients in Scotland: a national registry linkage study.
Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cancer-related mortality among solid organ transplant recipients: systematic review and meta-analysis.Frontiers in transplantation · 2026Pooled it
- Pan-cancer polygenic risk score associates with cancer susceptibility following kidney transplantation.JCI insight · 2026Article
- Kidney Transplant Recipients: Viral Infections and Malignancies.Pathogens (Basel, Switzerland) · 2026Observational
- Review
- Post-Transplant Double Malignancy: Multiple Myeloma and Papillary Renal Cell Carcinoma-A Case Report.Reports (MDPI) · 2025Article
- Long-term cancer risk after kidney transplantation: a German primary care cohort study.British journal of cancer · 2025Article
- Urgent considerations on renal immune-related adverse events in oncology practice.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer is a major contributor to morbidity following kidney transplantation. This study examines the incidence of cancer in kidney transplant recipients (KTRs) in Scotland, compares this to the general population, and identifies factors associated with cancer development.
methodsThis nationwide cohort study utilised data from the Scottish Renal Registry, Scottish Cancer Registry and hospitalisation records. Standardised incidence rate ratios (SIRs) compared cancer incidence to the general population. Cox proportional hazards models identified factors associated with post-transplant cancer.
resultsBetween 1997-2021, 4033 patients ≥18 years received a first kidney transplant. 770 developed cancer versus 194 expected (SIR 3.9, 95% CI 3.7-4.2). Site-specific SIRs were greatest for non-melanomatous skin cancer, lymphoma and kidney cancer. Cancer incidence was 7-times that of the general population in kidney transplant recipient (KTR) under 40, the increased incidence fell to 3-times for KTRs over 60. Consistent differences in the incidence of the most common cancers in the general population (colorectal, lung breast, prostate) were not detected in this population.
conclusionsThere is an increased risk of cancer in KTRs, particularly younger individuals. Non-melanomatous skin cancers remain the most frequent cancer in a population with low natural UV exposure. Tailored counselling and surveillance strategies are needed to improve patient outcomes.
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