Evidence map›Paper›PMID 40517012›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025

Tumor necrosis factor-α in the mediation of acute salt loading induced natriuresis in mice; evidence for its physiological role in regulating kidney function.

Dewan Syed Abdul Majid, Alexander Castillo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dewan Syed Abdul MajidDepartment of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana, United States.ORCID 0000-0001-8470-5283
Alexander CastilloDepartment of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana, United States.

Funding

Translational Research in Hypertension and Renal BiologyP30GM103337 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI NAVAR, LUIS GABRIEL · 2012 to 2016
$5.8M
Superoxide and nitric Oxide Interactions in the KidneyR01HL066432 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MAJID, DEWAN SYED ABDUL · 2001 to 2012
$3.0M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) P30GM103337NHLBI NIH HHS R01 HL066432NIGMS NIH HHS P30 GM103337Tulane University (TU) Bridge Fund
6 · The paper itself

Abstract

Tumor necrosis factor-α (TNF-α) exerts natriuresis via activation of its receptor type 1 in the kidney. Although chronic high salt (HS) intake produces this cytokine by immune activation of the mononuclear phagocyte cells, it has not yet been examined whether acute salt loading produces this cytokine and can induce consequent natriuresis. Here, we measured the changes in plasma level and urinary excretion rate of TNF-α (U

Indexed as

KidneyNatriuresisSodium Chloride, DietaryTumor Necrosis Factor-alphaAnimalsEtanerceptMaleMiceMice, Inbred C57BLSodiumEtanerceptSodiumSodium Chloride, DietaryTnf protein, mouseTumor Necrosis Factor-alphaacute salt loadingetanerceptnatriuresisTNF-αTNF-α receptor type 1

Identifiers

PMID40517012
PMCPMC12288672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.