Evidence map›Paper›PMID 40516285›Full record

ArticleEnvironment international2025

A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects.

Jongeun Rhee, Adrian M Michalski, Margaret Gates Kuliszewski, Jamie Musco, Catherine T Adler, Shuai Xie, Melissa C Friesen, Tabassum Insaf, Mark P Purdue

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Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Jongeun RheeOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Adrian M MichalskiBureau of Environmental & Occupational Epidemiology, New York State Department of Health, Albany, NY, USA; Birth Defects Registry, New York State Department of Health, Albany, NY, USA.
Margaret Gates KuliszewskiBureau of Cancer Epidemiology, New York State Department of Health, Albany, NY, USA; Birth Defects Registry, New York State Department of Health, Albany, NY, USA; Department of Epidemiology & Biostatistics, University at Albany, Albany, NY, USA.
Jamie MuscoBureau of Cancer Epidemiology, New York State Department of Health, Albany, NY, USA.
Catherine T AdlerBureau of Environmental & Occupational Epidemiology, New York State Department of Health, Albany, NY, USA.
Shuai XieOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Melissa C FriesenOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Tabassum InsafBureau of Cancer Epidemiology, New York State Department of Health, Albany, NY, USA; Birth Defects Registry, New York State Department of Health, Albany, NY, USA.
Mark P PurdueOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. Electronic address: purduem@mail.nih.gov.

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

backgroundResidential buildings with a co-located dry-cleaning facility (CL-DC) can have substantially higher indoor tetrachloroethylene concentrations than buildings without a CL-DC. We conducted a case-control study to investigate associations between early-life indoor tetrachloroethylene exposure from CL-DCs and risks of childhood cancers (overall, acute lymphoblastic leukemia) and birth defects.

methodsWe linked records between the New York City (NYC) Bureau of Vital Statistics and the New York State Cancer Registry and Birth Defects Registry to identify cases of childhood cancers (n = 5,334) and birth defects (n = 171,553) diagnosed among children born in NYC between 1988 and 2016, and controls without these conditions (n = 596,599). We identified CL-DC exposure by mapping addresses from birth certificates and DC permits involving tetrachloroethylene use to building footprints, and modeled tetrachloroethylene concentrations using measurement data from a survey of NYC CL-DCs. Using unconditional logistic regression, we computed odds ratios (ORs) and 95 % confidence intervals (CIs) relating study endpoints to CL-DC exposure.

findingsLiving in a building with a CL-DC at birth was associated with aortic valve stenosis (AVS; OR = 3.1, 95 % CI = 1.6, 5.9), with an exposure-response effect for predicted tetrachloroethylene concentration (≤44 μg/m

conclusionsIn this first-ever case-control study, early-life tetrachloroethylene exposure from CL-DCs in residential buildings was associated with increased AVS risk. These findings warrant further investigation.

Indexed as

Air Pollution, IndoorCongenital AbnormalitiesEnvironmental ExposureNeoplasmsTetrachloroethyleneCase-Control StudiesChildChild, PreschoolFemaleHousingHumansInfantInfant, NewbornMaleNew York CityTetrachloroethyleneAortic valve stenosisBirth defectsChildhood cancerDry-cleaning facilityTetrachloroethylene

Identifiers

PMID40516285
PMCPMC12235603

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