Evidence map›Paper›PMID 40516230›Full record

ArticleJournal of geriatric oncology2025

Association of intraindividual variability in simple reaction time with balance and falls in older cancer survivors: A secondary analysis.

Brendan L McNeish, C M S Shores, Sarah G Bell, Kim Dittus, Jurdan Mossburg, Nicholas Krant, Jack A Steinharter, Kendall Feb, Michael K Hehir, Mark S Redfern and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brendan L McNeishDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA; Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA. Electronic address: mcneish@pitt.edu.
C M S ShoresDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.. Electronic address: CMS402@pitt.edu.
Sarah G BellDepartment of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA, USA.
Kim DittusDepartment of Medicine, University of Wisconsin, Madison, WI, USA; Department of Physical Therapy, University of Vermont, Burlington, VT, USA.. Electronic address: kdittus@wisc.edu.
Jurdan MossburgDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Nicholas KrantDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA. Electronic address: Nicholas.krant@seattlechildrens.org.
Jack A SteinharterDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Kendall FebDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Michael K HehirDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA. Electronic address: Michael.Hehir@uvmhealth.org.
Mark S RedfernDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.. Electronic address: mredfern@pitt.edu.
Caterina RosanoDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: RosanoC@edc.pitt.edu.
James K RichardsonDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA. Electronic address: jkrich@med.umich.edu.
Noah KolbDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA. Electronic address: noah.kolb@uvmhealth.org.

Funding

NIA NIH HHS L30 AG083934
6 · The paper itself

Abstract

introductionIntraindividual reaction time variability (IIRV) is associated with physical function and falls in older cancer-free adults but has been minimally studied in aging cancer survivors. The aims of this study were (a) to assess the association of IIRV with physical function and falls in chemotherapy-treated cancer survivors, (b) to determine if this relationship varied between middle-aged and older cancer survivors, and (c) to determine if any associations are independent of reaction response central tendency (i.e., total reaction accuracy) and locomotor impairment. MATERIALS AND

methodsFifty cancer survivors (n = 28 with age ≥ 65 years, 88 % female) post chemotherapy treatment were included in this cross-sectional study. Simple IIRV was defined as the standard deviation of simple reaction time from stick drop paradigm. Physical function was measured by time to complete five sit-to-stand (5STS), number of sit-to-stand repetitions in thirty seconds (STS30), and unipedal stance time (UST). Self-reported recurrent and injurious falls in the past year were recorded as secondary outcomes. Bivariate analyses were conducted between IIRV measures and physical function variables in middle-aged and older aged cancer survivors. Multivariable models were used to examine the associations of simple IIRV with UST and falls outcomes. Included covariates were age, total reaction accuracy, a measure of central reaction tendency, and presence of a locomotor risk factor (obesity or neuropathy).

resultsIn older cancer survivors, Spearman correlations demonstrated significant relationships of simple IIRV with UST and STS30, but not STS. In multivariable models, the interaction of age ≥ 65 years with increasing levels of simple IIRV was independently associated with worse UST (B -0.919, 95 % CI -1.68, -0.159, p = 0.02), increased recurrent falls (OR 1.29, 95 % CI,1.04 1.61, p = 0.02), and injurious falls (OR 1.30, 95 % CI,1.04 1.63, p = 0.02). DISCUSSION: Simple IIRV was independently associated with balance and falls outcomes in older chemotherapy-treated cancer survivors. The relationship of IIRV to balance and falls did not extend to middle-aged cancer survivors, suggesting that IIRV may be of greater importance for cognitive motor control in older cancer survivors.

Indexed as

Accidental FallsCancer SurvivorsNeoplasmsPostural BalanceReaction TimeAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedAgedcancer survivorChemotherapy induced peripheral neuropathyChemotherapy-related cognitive impairmentExecutive function

Identifiers

PMID40516230
PMCPMC12375906

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