Protocol for modeling earned-secure attachment in rodents using the repeated cross-fostering procedure with a significant alternative caregiver.

Camilla Mancini, Alice Passeri, Matteo Di Segni, Lucy Babicola, Rossella Ventura

Abstract read

In one paragraph

Article in STAR protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Camilla ManciniSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Macerata, Italy. Electronic address: camilla.mancini@unicam.it.

Alice PasseriDepartment of Psychology, Sapienza University, 00185 Rome, Italy.

Matteo Di SegniChild Psychopathology Unit, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.

Lucy BabicolaDepartment of Experimental Neurosciences, IRCCS Santa Lucia Foundation, 00143 Rome, Italy.

Rossella VenturaDepartment of Psychology, Sapienza University, 00185 Rome, Italy; IRCCS San Raffaele, 00166 Rome, Italy. Electronic address: rossella.ventura@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An earned-secure attachment (ESA) from a significant alternative caregiver (SAC) can mitigate the negative effects of the alteration of attachment bond. This protocol models clinical ESA in rodents using the repeated cross-fostering procedure with a SAC (RCF+SAC). We describe steps for housing of mice, the mating procedure, isolation of pregnant dam, and SAC introduction. We then detail the preparation of materials and environment for the RCF+SAC procedure and its subsequent execution. For complete details on the use and execution of this protocol, please refer to Mancini et al.

Indexed as

Behavior, AnimalCaregiversObject AttachmentAnimalsFemaleHousing, AnimalMaleMicePregnancyBehaviorCognitive NeuroscienceNeuroscience

Identifiers

PMID40516046

DOI10.1016/j.xpro.2025.103888

PMCPMC12205338

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LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.