Evidence map›Paper›PMID 40516005›Full record

ReviewCell biology and toxicology2025

From neurotoxicity to neuroprotection: Rethinking GABA

Yubao Li, Hongliang Yang, Lu Liu, Lulu Jiang, Peilin Xie, Xiaoling Wang, Xuhui Cong, Ruilou Zhu, Zhongyuan Lu, Mingyang Sun and 1 more

Abstract readReview
In one paragraph

Review in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Pathophysiology and Prognostic Significance of Myoclonus in Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yubao LiXinxiang Medical University, Xinxiang, Henan, China.
Hongliang YangXinxiang Medical University, Xinxiang, Henan, China.
Lu LiuDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Lulu JiangDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Peilin XieDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xiaoling WangDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xuhui CongDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Ruilou ZhuDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Zhongyuan LuDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Mingyang SunDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China. znxyfs@zzu.edu.cn.
Jiaqiang ZhangDepartment of Anesthesiology and Perioperative Medicine, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, Henan, China. zhangjiq@zzu.edu.cn.

Funding

National Natural Science Foundation of China 82271288
6 · The paper itself

Abstract

The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enhances learning and memory abilities, while also increasing the brain's susceptibility to disruptions. Anesthetics, particularly those targeting γ-aminobutyric acid type A receptors (GABA

Indexed as

AnestheticsNeuroprotectionNeuroprotective AgentsNeurotoxicity SyndromesReceptors, GABA-AAnimalsBrainBrain-Derived Neurotrophic FactorHumansOxidative StressAnestheticsBrain-Derived Neurotrophic FactorNeuroprotective AgentsReceptors, GABA-AAnesthetics targeting GABAARsNeuroactive steroidsNeurodevelopmentNeuroprotectiveNeurotoxicity

Identifiers

PMID40516005
PMCPMC12167312

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.