Evidence map›Paper›PMID 40515975›Full record

ArticleMolecular neurobiology2025

Altered Lipid Homeostasis in Mutant FUS

Yingli Zhu, Katrien Neyrinck, Thibaut Burg, Yoke Chin Chai, Fatemeharefeh Nami, Karan Ahuja, Johannes V Swinnen, Ludo Van Den Bosch, Catherine Verfaillie

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingli Zhu *Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Louvain, Belgium. zhuyingli1992@163.com.
Katrien Neyrinck *Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Louvain, Belgium.
Thibaut Burg *KU Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), 3000, Leuven, Belgium.
Yoke Chin ChaiDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Louvain, Belgium.
Fatemeharefeh NamiDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Louvain, Belgium.
Karan AhujaDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Louvain, Belgium.
Johannes V SwinnenLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, 3000, Louvain, Belgium.
Ludo Van Den BoschKU Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), 3000, Leuven, Belgium.
Catherine VerfaillieDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Louvain, Belgium.

Funding

China Scholarship Council 201908440360Fonds Wetenschappelijk Onderzoek 12AIK24NFonds Wetenschappelijk Onderzoek FWO-SBO-S001221N -ORGAN-IDUniversity of Leuven C1 grants C14-17-107
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron loss, leading to paralysis and death. Mutations in the fused in sarcoma (FUS) gene cause early-onset ALS with rapid disease progression. Although motor neuron degeneration is central to ALS, recent studies highlight a significant role for dysfunctional glial cells, particularly astrocytes, in disease progression. In this study, we generated astrocytes from FUS

Indexed as

AstrocytesHomeostasisInduced Pluripotent Stem CellsLipid MetabolismMutationRNA-Binding Protein FUSHumansMotor NeuronsRNA-Binding Protein FUS

Identifiers

PMID40515975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.