ReviewCurrent gastroenterology reports2025
Managing Pouchitis: Where do Antibiotics End, and Advanced Therapies Begin?
Review in Current gastroenterology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewPouchitis is a common complication in patients with ulcerative colitis who undergo total colectomy with ileal pouch anal anastomosis that presents a challenge to clinicians. In the article, we review the management of patients with pouchitis based on best available evidence. RECENT
findingsPouchitis can be practically classified into acute intermittent pouchitis (AIP), chronic antibiotic dependent pouchitis (CADP) and chronic antibiotic refractory pouchitis (CARP) based on the frequency of pouchitis episodes and response to antibiotics. Antibiotics are effective for treatment of AIP and CADP. However, prolonged antibiotic use, which is often necessary in CADP, may be associated with the risk of side effects and antibiotic resistance. Advanced immunosuppressive therapy can be a reasonable alternative to antibiotics in CADP. Advanced immunosuppressive therapies are effective in CARP and Crohn's like disease of the pouch (CLDP) and are the recommended treatments for these conditions. Evaluation to confirm pouchitis and rule out other etiologies that can present with pouchitis-like symptoms should be considered in antibiotic refractory patients. Antibiotics are the mainstay of medical treatment of pouchitis. Advanced immunosuppressive therapies can be effective in situations where antibiotics are not preferred or are ineffective. The treatment targets in pouchitis need to be better defined.
Indexed as
Identifiers
40515946What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.