Evidence map›Paper›PMID 40515939›Full record

ArticleBiological trace element research2026

Effects of Exposure to Chromium During Pregnancy on Fetal Growth and a Possible Sex-Dependent Response: Results of Cross-sectional Study.

Yuanyuan Fang, Qingmei Shen, Kuanying Yang, Meng Wang, Wenxin Wang, Jia Lv, Mingliang Fang, Min Nian, Yichao Huang, Zhaohui Huang and 3 more

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuanyuan FangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China.
Qingmei ShenDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China.
Kuanying YangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China.
Meng WangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China.
Wenxin WangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China.
Jia LvDepartment of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, 81 Meishan Rd, Hefei, 230032, China.
Mingliang FangDepartment of Environmental Science and Engineering, Fudan University, Shanghai, 200433, China.
Min NianDepartment of Environmental Science and Engineering, Fudan University, Shanghai, 200433, China.
Yichao HuangDepartment of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, 81 Meishan Rd, Hefei, 230032, China.
Zhaohui HuangAnhui Provincial Center for Women and Child Health, Hefei, 230032, Anhui, China.
Liping CuiDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China.
Dexiang XuDepartment of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, 81 Meishan Rd, Hefei, 230032, China. xudex@ahmu.edu.cn.
Yijun FanDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, No 678 Furong Road, Hefei, 230601, Anhui, China. fanyijun@ahmu.edu.cn.

Funding

the Clinical Research and Cultivation Program of The Second Affiliated Hospital of Anhui Medical University 2021LCZD05the National Natural Science Foundation Incubation Program of The Second Affiliated Hospital of Anhui Medical University 2020GMFY01the Nature Science Research Project of Anhui Province 2208085MH205
6 · The paper itself

Abstract

Fetal growth restriction (FGR) or small for gestational age (SGA) is a serious birth outcome affected by environmental factors. Animal studies have shown that prenatal chromium (Cr) exposure leads to intrauterine growth restriction and reduced birth weight in fetal rats. However, evidence remains limited in human studies. Our study aimed to examine the association between maternal urinary Cr levels during pregnancy and also investigated possible sex-dependent response. Our cross-sectional study included 1,220 women with singleton pregnancies in the third trimester (38.31 ± 1.82 weeks). Maternal urinary Cr levels were quantified using inductively coupled plasma mass spectrometry (ICP-MS). Subsequently, the relationship between Cr exposure and SGA was evaluated using logistic regression analysis. Our investigation has found that the incidence of SGA was 13.2% in the high-exposure group (urinary Cr ≥ 14.76 µg/L; n = 305) compared to 4.6% in the low-exposure group (urinary Cr < 14.76 µg/L; n = 915; P = 0.004). The risk of SGA increased 6.2-fold for each unit increase in the normalized Cr levels in the newborns when the maternal urinary Cr concentration was > 26.15 µg/L. After adjusting for covariates, disparities were observed in the urinary Cr exposure among SGA infants based on their sex. Specifically, male infants with high Cr exposure had a higher risk of SGA than those with low exposure (odds ratio, 3.2; 95% confidence interval: 1.73, 6.04). Study found that maternal Cr exposure can affect SGA. Moreover, sex-specific implications of Cr on fetal development were observed, with male infants showing a higher susceptibility than the female.

Indexed as

ChromiumFetal DevelopmentFetal Growth RetardationMaternal ExposureAdultCross-Sectional StudiesFemaleHumansInfant, NewbornInfant, Small for Gestational AgeMalePregnancySex FactorsChromiumChromiumFetal growth restrictionSex differencesSmall for gestational age

Identifiers

PMID40515939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.