Applying Phage Display Technology to Obtain Specific Peptides Blocking Host-Virus Interactions.

Ting Wang, Yiqiang Wang

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ting WangOncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. wangting921204@ahmu.edu.cn.

Yiqiang WangWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China. Yiqiang.Wang@xjtlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage display (PhD) has been proven to be a powerful tool for studying interactions when at least one partner of the interplay is of protein or peptide nature. In this chapter, PhD was utilized to search for peptides potentially binding onto the receptor-binding domain of spike proteins (S-RBD) of the SARS-CoV-2 virus. After three rounds of PhD selection, two peptides were identified to be able to dock onto the positions critical for S-RBD functions, validating the usefulness of PhD in the studies concerning host-virus interactions.

Indexed as

Cell Surface Display TechniquesHost Microbial InteractionsHost-Pathogen InteractionsPeptidesSARS-CoV-2Spike Glycoprotein, CoronavirusCOVID-19HumansPeptide LibraryProtein BindingPeptide LibraryPeptidesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Host–pathogen interactionHost–virus interactionPhage displaySARS-CoV-2Spike proteinSteric peptide

Identifiers

PMID40515926

DOI10.1038/s41586-020-2180-5

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.