ArticleMetabolomics : Official journal of the Metabolomic Society2025
Faecal amino acids stability: investigating optimal sampling conditions for analysis.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Colorectal neoplasia-specific amino acid profiles and their diagnostic potential: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Longitudinal fecal amino acid profiles in extremely preterm infants: early-life determinants and associations with late-onset sepsis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Gut Microbiota-Metabolite Alterations Associated with Early Metabolic Dysfunction and Hepatic Steatosis in Adolescents.Computational and structural biotechnology journal · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
introductionFaecal amino acids are promising non-invasive diagnostic biomarkers, but stability remains unclear.
objectivesThis study examined whether storage conditions, sampling site within the sample, freeze-thaw cycles, and the OMNImet
methodsFaecal samples from three donors underwent various pre-analytical conditions. Amino acids were analysed through targeted liquid chromatography-tandem mass spectrometry.
resultsMost amino acids remained stable across sampling sites and freeze-thaw cycles. Storage at -20 °C preserved integrity, whereas 4 °C and 20 °C storage led to variations. The OMNImet
conclusionPre-analytical conditions influence faecal amino acid concentrations. Standardisation is essential for biomarker reliability.
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