ArticleCellular and molecular life sciences : CMLS2025
Preliminary investigation of the epigenetic regulation of KMT2D via H3K4me1/H3K27ac in oral squamous cell carcinoma.
Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Paeoniflorin inhibits colorectal cancer stem cell properties via regulating LINC01711/KMT2D/KLF7 axis.Journal of gastrointestinal oncology · 2026Article
- Dissecting the role of epigenetic regulation in oral squamous cell carcinoma microenvironment: mechanisms and therapeutics.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Histone lysine methyltransferase 2D (KMT2D/MLL4) critically modulates gene expression by methylating and acetylating histones H3K4/H3K27, thereby regulating the expression of specific target genes. Although KMT2D is highly mutated in a variety of cancers, its role in the progression of oral squamous cell carcinoma (OSCC) remains unclear. The purpose of this study was to reveal the significance of KMT2D expression in OSCC and to preliminarily explore the regulatory effect of KMT2D on the expression of OSCC-related genes by influencing histone modifications. In this study, through immunohistochemistry, gene editing, RNA-Seq, ATAC-seq, CHI-Seq and combined analysis, the following conclusions were drawn: KMT2D plays a role in histone modification, chromatin opening and gene transcription translation in oral squamous cell cancer cells. Integrated multi-omics data analysis indicated that KLF7 and TPO may be target genes regulated by KMT2D.
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