Evidence map›Paper›PMID 40515832›Full record

Trial reportRheumatology international2025

Estimating pain visual analogue scale from health assessment questionnaire for rheumatoid arthritis with beta mixture models.

Sean P Gavan, Sainan Chang, Felice Rivellese, Zoë Ide, Michael Stadler, Katherine Payne, Darren Plant, Anne Barton, Costantino Pitzalis

Abstract readClinical Trial, Phase IVMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sean P GavanManchester Centre for Health Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK. sean.gavan@manchester.ac.uk.ORCID 0000-0003-3659-056X
Sainan ChangManchester Centre for Health Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK.ORCID 0009-0004-3208-9799
Felice RivelleseCentre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK.ORCID 0000-0002-6759-7521
Zoë IdePatient Researcher, The University of Manchester, Manchester, UK.
Michael StadlerVersus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0003-3689-4256
Katherine PayneManchester Centre for Health Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK.ORCID 0000-0002-3938-4350
Darren PlantVersus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0003-1395-9344
Anne BartonVersus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0003-3316-2527
Costantino PitzalisCentre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK.ORCID 0000-0003-1326-5051

Funding

National Institute for Health and Care Research NIHR203308National Institute for Health and Care Research NIHR203330National Institute for Health and Care Research NIHR204342
6 · The paper itself

Abstract

To map from the health assessment questionnaire disability index (HAQ) to the pain visual analogue scale (VAS) for people with rheumatoid arthritis. The estimation sample comprised adults with rheumatoid arthritis and inadequate response to tumour necrosis factor-α inhibitors in a multicentre phase 4 randomised controlled trial. Beta mixture models were estimated with combinations of HAQ and its square, age and sex as independent variables. Bayesian Information Criteria informed the number of components. Model performance (root mean squared error; mean absolute error; pseudo-R

Indexed as

Arthritis, RheumatoidDisability EvaluationPain MeasurementVisual Analog ScaleAdultAgedAntirheumatic AgentsBayes TheoremFemaleHumansMaleMiddle AgedReproducibility of ResultsSeverity of Illness IndexSurveys and QuestionnairesAntirheumatic AgentsBeta mixture modelHealth assessment questionnaireMappingPainPatient-reported outcomesRheumatoid arthritisVisual analogue scale

Identifiers

PMID40515832
PMCPMC12167326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.