ArticleJapanese journal of ophthalmology2025
Reduction in choroidal thickness associated with the progression of pachychoroid spectrum diseases.
Article in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Patterns of Choroidal Configuration in Pachychoroid Spectrum Disease.Ophthalmology science · 2026Article
- Evaluation of anterior scleral thickness in pachychoroid pigment epitheliopathy, central serous chorioretinopathy and pachychoroid neovasculopathy.Japanese journal of ophthalmology · 2026Article
- Subtype-specific shifts in age, axial length, and clinical profile of neovascular age-related macular degeneration: a five-year study in Japan.Japanese journal of ophthalmology · 2026Observational
- Choroidal changes correlate with type 1 neovascular activity in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.The British journal of ophthalmology · 2026Observational
- Evaluation of longitudinal changes in choroidal thickness during pregnancy and postpartum using widefield swept-source optical coherence tomography.Scientific reports · 2025Observational
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Authors and funding
6 authors.
Funding
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Abstract
purposePachychoroid spectrum diseases reportedly progress from central serous chorioretinopathy (CSC) to pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). We investigated and compared choroidal thicknesses in the macular and peripheral areas among eyes with CSC, PNV, and PCV, as well as in normal control eyes. STUDY
designRetrospective case-control study.
methodsWe studied 117 consecutive eyes with treatment-naïve pachychoroid spectrum diseases, comprising 52 eyes with CSC, 27 with PNV, and 38 with PCV, along with 106 age-, gender-, and axial length-matched normal control eyes. Widefield choroidal thickness maps generated by widefield optical coherence tomography were quantitatively analyzed. Mean choroidal thickness values in the macular, superotemporal, inferotemporal, superonasal, and inferonasal areas were determined, and then compared among the three pachychoroid spectrum diseases, and also assessed in normal controls.
resultsThe mean choroidal thickness reduction with aging was greater in eyes with pachychoroid spectrum diseases than in normal controls across all measured areas. Patient age increased in the order of CSC, PNV, and PCV, whereas there was no significant difference between PNV and PCV (P<0.01, CSC vs. PNV, CSC vs. PCV). Mean choroidal thickness exhibited a progressive decrease from CSC to PNV and PCV across all areas, although there were no significant differences between PNV and PCV (P<0.01, CSC vs. PCV, CSC vs. PNV).
conclusionsOverall choroidal thickness appears to decrease during the progression of pachychoroid spectrum diseases. This decline might be attributable to reduced choroidal blood flow due to the choriocapillaris attenuation associated with aging and pachychoroid pathophysiology.
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