ArticleCancer2025
Early phase study enrollment in Canadian children with cancer near end of life: A retrospective cohort study from Cancer in Young People in Canada.
Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Impact of Distance and Income on Pediatric Solid Extracranial Tumors: A Report From CYP-C.Cancer medicine · 2026Article
- Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundLittle is known about children with cancer who participate in early phase (phase 1/2) oncology trials toward the end of life (EOL). The authors sought to describe the proportion of Canadian children with cancer who participate in trials in their last 90 days, explore predictors of enrollment, describe these trials and key EOL outcomes.
methodsThis retrospective cohort study used data from the Cancer in Young People in Canada (CYP-C) database, a national population-based registry. The study included Canadian children and adolescents with cancer 0-20 years old at death, who died from 2001 to 2021. We performed logistic regression to explore the relationships between diagnosis-related factors, treatment-related factors, demographic factors, and study enrollment.
resultsOf 3125 children and adolescents who died, 140 (4.5%) met study criteria. Patients with leukemia or lymphoma (odds ratio [OR], 0.54; 95% confidence interval [CI], 0.33-0.87) or a solid tumor (OR, 0.48; 95% CI, 0.29-0.79) enrolled less frequently than those with central nervous system tumors. Previous trial enrollment (OR, 3.02; 95% CI, 2.43-3.77), and initial treatment in a major early phase study center (OR, 1.65; 95% CI, 1.14-2.4) were associated with enrollment. Patients in the lowest census-based income quintiles (quintiles 1-2) enrolled less frequently than those in the highest quintiles (3-5) (OR, 0.56; 95% CI, 0.37-0.84).
conclusionsA small proportion of children and adolescents participate in early phase trials toward EOL. Diagnosis, treatment-related, and socioeconomic factors are associated with non-enrollment. Clinicians, researchers, and policy developers should consider and address the possible impact of socioeconomic and other factors on access to studies, to ensure equitable access for diverse populations.
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