Evidence map›Paper›PMID 40515531›Full record

ArticleActa biochimica et biophysica Sinica2025

FOXD3 promotes homologous recombination repair and genomic stability by facilitating MRE11-mediated DNA end resection.

Shibin Xu, Jingyu Zhang, Congwen Gao, Ziyi Xiong, Yamin Gong, Bao Chai, Hongxiang Chen, Xingzhi Xu

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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Shibin XuDepartment of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518052, China.
Jingyu ZhangDepartment of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518052, China.
Congwen GaoGuangdong Key Laboratory for Genome Stability & Disease Prevention, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
Ziyi XiongGuangdong Key Laboratory for Genome Stability & Disease Prevention, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
Yamin GongGuangdong Key Laboratory for Genome Stability & Disease Prevention, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
Bao ChaiDepartment of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518052, China.
Hongxiang ChenDepartment of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital/The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518052, China.
Xingzhi XuGuangdong Key Laboratory for Genome Stability & Disease Prevention, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homologous recombination (HR) is crucial for the high-fidelity repair of DNA double-strand breaks (DSBs), ensuring the maintenance of genome stability. In this study, we show that FOXD3 interacts with poly (ADP-ribose) polymerase 1 (PARP1) and is recruited to DSBs in a PARP1-dependent manner. FOXD3 directly binds to the DSB repair protein MRE11 and promotes its recruitment to DSB sites, ensuring proper end resection. Inhibition of FOXD3 expression compromises HR-mediated DSB repair and chromosome stability and sensitizes cancer cells to ionizing radiation. Collectively, our findings demonstrate that FOXD3 promotes HR-mediated DSB repair and genome stability.

Indexed as

Forkhead Transcription FactorsGenomic InstabilityMRE11 Homologue ProteinRecombinational DNA RepairCell Line, TumorDNA Breaks, Double-StrandedHumansPoly (ADP-Ribose) Polymerase-1Forkhead Transcription FactorsMRE11 Homologue ProteinMRE11 protein, humanPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1end resectionFOXD3homologous recombinationMRE11

Identifiers

PMID40515531
PMCPMC12616725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.