Evidence map›Paper›PMID 40515488›Full record

ArticleAnnals of neurology2025

Midlife Steroid-Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women.

Rachel F Buckley, Matthew Scott, Emer R McGrath, Gillian Coughlan, Mabel Seto, Saptaparni Ghosh, Heidi I L Jacobs, Claudia L Satizabal, Emma Thibault, Vasan Ramachandran and 7 more

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Article in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rachel F BuckleyDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-5356-5537
Matthew ScottFramingham Heart Study, Framingham, MA.
Emer R McGrathFramingham Heart Study, Framingham, MA.
Gillian CoughlanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-1806-702X
Mabel SetoCenter for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, MA.
Saptaparni GhoshDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Heidi I L JacobsDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-7620-3822
Claudia L SatizabalGlen Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX.ORCID 0000-0002-1115-4430
Emma ThibaultDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Vasan RamachandranDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Joanne M MurabitoSection of General Internal Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Reisa A SperlingDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Keith A JohnsonDepartment of Medicine, Boston University School of Medicine, Boston, MA.
Ravi JasujaDepartment of Medicine, Brigham and Women's Hospital, Boston, MA.
Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Sudha SeshadriDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Alexa S BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.

Funding

PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
MRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young AdultsR01AG033040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 2009 to 2019
$11.2M
Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1M
Building predictive algorithms to identify resilience and resistance to Alzheimer's diseaseR01AG079142 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Rachel Frances Buckley, Michael C Donohue · 2023 to 2026
$4.0M
Identification of a missing key element underlying apoE2 neuroprotection in Alzheimer's disease and the aging brainRF1AG061872 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HAN, XIANLIN, SESHADRI, SUDHA · 2018 to 2018
$3.4M
Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young AdultsR01AG049607 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2015 to 2019
$3.1M
The inactive X: discovering sex genes that influence female vulnerability to Alzheimer's diseaseDP2AG082342 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Rachel Frances Buckley · 2022 to 2026
$2.5M
Sex differences in the progression of Alzheimer's disease: is menopause the key?R00AG061238 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKLEY, RACHEL FRANCES · 2021 to 2023
$747k
Elucidating the mechanisms underlying sex differences in cognitive decline due to preclinical Alzheimer's diseaseK99AG061238 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKLEY, RACHEL FRANCES · 2019 to 2020
$273k
Menopause, hormone therapy and Alzheimer's disease clinicopathology: An in vivo perspectiveK99AG083063 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI COUGHLAN, GILLIAN THERESA · 2024 to 2025
$269k
NIA NIH HHS AG033040NIA NIH HHS AG049607NIA NIH HHS AG054076NIA NIH HHS AG058589NIA NIH HHS AG061238NIA NIH HHS AG061872NIA NIH HHS AG079142NIA NIH HHS AG082342NIA NIH HHS AG083063NIA NIH HHS DP2 AG082342NIA NIH HHS K99 AG061238NIA NIH HHS K99 AG083063NIA NIH HHS NS017950NIA NIH HHS R00 AG061238NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG079142NIA NIH HHS RF1 AG061872NIA NIH HHS U01 AG058589NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

objectiveIn men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later-life in vivo markers of β-amyloid (Aβ) and tau deposition in clinically healthy older men.

methodsThis time-lagged study includes participants enrolled in the Framingham Heart Study (FHS) Third Generation cohort. One hundred fifty-nine men (mean age

resultsIn men, the elevated SHBG level was associated with lower tau-PET in entorhinal (B

interpretationWe report a potential protective effect of SHBG levels on tau-PET burden in men. Higher levels of SHBG have been associated with lower risk of vascular-related comorbidities, such as obesity and diabetes, and is regulated by modifiable lifestyle factors. Given mounting evidence of a link between vascular injury and tauopathy in preclinical AD, our findings suggest an intriguing protective cardiovascular pathway for men against higher tau burden later in life. ANN NEUROL 2025;98:524-532.

Indexed as

BrainSex Hormone-Binding Globulintau ProteinsTestosteroneAgedAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedNeuroimagingPositron-Emission TomographyAmyloid beta-PeptidesBiomarkersMAPT protein, humanSex Hormone-Binding GlobulinSHBG protein, humantau ProteinsTestosterone

Identifiers

PMID40515488
PMCPMC12392056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.