Evidence map›Paper›PMID 40515424›Full record

ArticleExperimental physiology2026

Submaximal 2-day cardiopulmonary exercise testing to assess exercise capacity and post-exertional symptom exacerbation in people with long COVID.

Callum Thomas, Nik Kudiersky, Paul Ansdell, Ruth E Ashton, Calum Brown, Thomas Bewick, Jack Carr, Emily Hume, Padraig Spillane, Elisa Pastorio and 10 more

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Callum ThomasBiomedical and Clinical Science Research Theme, School of Human Sciences, University of Derby, Derby, UK.ORCID 0000-0001-8608-8231
Nik KudierskyPhysical Activity, Wellbeing and Public Health Research Group, School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, UK.
Paul AnsdellFaculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle upon Tyne, UK.ORCID 0000-0001-7542-1107
Ruth E AshtonResearch Centre for Physical Activity, Sport and Exercise Sciences (PASES), Coventry University, Coventry, UK.
Calum BrownPhysical Activity, Wellbeing and Public Health Research Group, School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, UK.
Thomas BewickDepartment of Respiratory Medicine, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Jack CarrResearch Centre for Physical Activity, Sport and Exercise Sciences (PASES), Coventry University, Coventry, UK.
Emily HumeFaculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle upon Tyne, UK.
Padraig SpillaneFaculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle upon Tyne, UK.
Elisa PastorioFaculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle upon Tyne, UK.ORCID 0000-0001-9028-303X
Rebecca OwenBiomedical and Clinical Science Research Theme, School of Human Sciences, University of Derby, Derby, UK.
Tom Maden-WilkinsonPhysical Activity, Wellbeing and Public Health Research Group, School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, UK.
Ethan McNeil-AngopaBiomedical and Clinical Science Research Theme, School of Human Sciences, University of Derby, Derby, UK.
Tom ParkingtonPhysical Activity, Wellbeing and Public Health Research Group, School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, UK.
Ross ArenaDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Cemal OzemekDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Federico FormentiCentre for Human and Applied Physiological Sciences, King's College London, London, UK.ORCID 0000-0003-4289-0761
Sundar Kumar VeluswamyM. S. Ramaiah College of Physiotherapy, M. S. Ramaiah University of Applied Sciences, Bengaluru, India.
Rachita GururajM. S. Ramaiah College of Physiotherapy, M. S. Ramaiah University of Applied Sciences, Bengaluru, India.
Mark A FaghyBiomedical and Clinical Science Research Theme, School of Human Sciences, University of Derby, Derby, UK.

Funding

Gilead Sciences IN-UK-983-6080
6 · The paper itself

Abstract

Long COVID has a complex pathology and a heterogeneous symptom profile that impacts quality of life and functional status. Post-exertional symptom exacerbation (PESE) affects one-third of people living with long COVID, but the physiological basis of impaired physical function remains poorly understood. Sixty-eight people (age (mean ± SD): 50 ± 11 years, 46 females (68%)) were screened for severity of PESE and completed two submaximal cardiopulmonary exercise tests separated by 24 h. Work rate was stratified relative to functional status and was set at 10, 20 or 30 W, increasing by 5 W/min for a maximum of 12 min. At the first ventilatory threshold (VT1),

Indexed as

COVID-19Exercise TestExercise ToleranceAdultExerciseFemaleHeart RateHumansMaleMiddle AgedOxygen ConsumptionSARS-CoV-2COVID‐19CPETlong COVIDPESE

Identifiers

PMID40515424
PMCPMC12857497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.