ArticleAnalytical chemistry2025
In-Line Enrichment of Cancer Cells from Whole Blood by Cell Self-Organization in Acoustic Fields.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- An inertial-acoustofluidic platform for bioanalysis: concurrent, high-precision, high-throughput separation of cells and bacteria.Analytical and bioanalytical chemistry · 2026Article
- Advances in machine learning-enhanced microfluidic cell sorting.Science advances · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a novel method for in-line acoustofluidic separation of cancer cells directly from whole blood. We report for the first time the observation that blood cells can self-organize when packed closely together in an acoustic field. We utilize this effect to enrich K-562 cancer cells and white blood cell subpopulations from whole blood at normal hematocrit levels. Further, we investigate the effect of self-organization of particles and cells with different sizes and acoustic properties. We propose that the mechanism for the phenomenon is based on the change of sign of the acoustic contrast of cancer cells relative to the densely packed red blood cells such that they are pushed to the RBC-plasma interface. This method may be useful as a rapid and gentle initial refinement stage for accessing rare cells, potentially enhancing point-of-care diagnostics and advancing treatments like immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.