Evidence map›Paper›PMID 40514748›Full record

ArticleInfectious diseases of poverty2025

Clinical features and outcomes of infective endocarditis in persons experiencing homelessness.

Torrance Teng, Kyle Crooker, Tess Hickey, Max HoddWells, Ashwini Sarathy, Sean Muniz, Jennifer Lor, Amy Chang, Bradley J Tompkins, Aaron O'Brien and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Torrance TengInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Kyle CrookerInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Tess HickeyInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Max HoddWellsInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Ashwini SarathyInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Sean MunizInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Jennifer LorInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Amy ChangInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Bradley J TompkinsInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Aaron O'BrienInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Elly RiserInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Devika SinghInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Jean DejaceInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA.
Andrew J HaleInfectious Disease Unit, University of Vermont Medical Center, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT, 05401, USA. Andrew.Hale@UVMhealth.org.ORCID http://orcid.org/0000-0001-7038-1353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfective endocarditis (IE) is associated with significant morbidity and mortality and current treatment guidelines recommend a prolonged course of intravenous antibiotics. However, individuals experiencing homelessness face greater barriers to standard IE care. The aim of this study was to compare IE characteristics and outcomes in an unhoused population versus a housed population.

methodsA retrospective cohort study encompassing 2010-2020 was conducted in Burlington, Vermont, comparing characteristics and outcomes of patients with IE who did or did not experience homelessness at the time of their infection. Primary outcomes included 30-day, 90-day, and 365-day mortality, IE-related mortality, and IE-related readmission rates. Secondary outcomes included rates of microbiologic failure and treatment failure.

resultsOf 378 included patients with IE, 30 (7.9%) experienced homelessness and 348 (92.1%) did not. The unhoused cohort was more likely to have right-sided IE involving the tricuspid valve (50.0% vs 21.6%, P = 0.006) and for the causative organism to be methicillin-resistant Staphylococcus aureus (MRSA) [9 (30.0%) vs 43 (12.4%), P = 0.039]. Mortality, IE-related mortality, and IE-related readmission rates were not significantly different between groups at any time point measured. For secondary outcomes, differences in microbiologic failure [5 (16.7%) vs 36 (10.3%), P = 0.543] and treatment failure [9 (30.0%) vs 105 (30.2%), P = 1.000] were also not statistically significant.

conclusionsFuture research should elucidate factors that entail increased risk of poor outcomes in this important underserved population and how to best mitigate them.

Indexed as

EndocarditisIll-Housed PersonsAdultAgedAnti-Bacterial AgentsFemaleHumansMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedPatient ReadmissionRetrospective StudiesStaphylococcal InfectionsAnti-Bacterial AgentsEndocarditisHomelessnessUnderservedUndomiciled

Identifiers

PMID40514748
PMCPMC12164142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.