Evidence map›Paper›PMID 40514738›Full record

ArticleExperimental hematology & oncology2025

Comprehensive molecular characterization of adult H3K27M mutated thalamic glioma long-term survivors.

Hao Xu, Xiaomu Hu, Biyun Wang, Ying Sun, Ye Wang, Qisheng Tang, Qiongji Zhu, Kun Song, Hong Chen, Lingchao Chen and 2 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology & oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hao Xu *Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Xiaomu Hu *Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
Biyun Wang *Department of Nursing, Huashan Hospital, Fudan University, Shanghai, China.
Ying SunGenomiCare Biotechnology (Shanghai) Co. Ltd, Shanghai, China.
Ye WangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Qisheng TangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Qiongji ZhuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Kun SongDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Hong ChenDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
Lingchao ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. chenlingchao12@sina.com.
Haixia ChengDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, China. chenghaixia99@126.com.
Zhiyong QinDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. qinzhiyong@fudan.edu.cn.

Funding

Beijing Xisike Clinical Oncology Research Foundation Y-zai2021/qn-0204Beijing Xisike Clinical Oncology Research Foundation Y-zai2021/zd-0207National Natural Science Foundation of China 82103376
6 · The paper itself

Abstract

H3K27-altered diffuse midline gliomas (H3-DMGs) represent aggressive tumors with fatal outcome and exceedingly rare cases have a long-term survival (LTS). We included 5 adult thalamic H3-DMG LTS and 13 short-term survivors (STS), and performed whole exome sequencing, RNA-seq and DNA methylation array. The median overall survival was 48.0 ± 12.1 months for LTS and 12.5 ± 5.9 months for STS. There was no significant difference in clinical characteristics and treatment received between LTS and STS. LTS exhibited more copy number gain and amplification (P = 0.007), and tumor microenvironment analysis revealed increased accumulation of M1 macrophage (P = 0.005) alongside a notable reduction in cancer-associated fibroblast in LTS (P = 0.037). The signatures of LTS and STS were signature 30 (similarity = 76.7%) and signature 6 (81.8%), respectively. Of note, LTS exhibited hypermethylated CpG island (P = 0.002). Additionally, we demonstrated that LTS and STS could be distinguished using differentially methylated probes. Collectively, the present study delineated unique molecular characteristics of LTS H3-DMG.

Indexed as

DNA methylation arrayH3K27-altered diffuse midline gliomaLong-term survivorMutation analysisRNA sequencing

Identifiers

PMID40514738
PMCPMC12166572

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