Evidence map›Paper›PMID 40514733›Full record

SynthesisPediatric rheumatology online journal2025

Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review.

Zahra Amirsardari, Mohammadmahdi Abbasi, Shana Ahadi, Aida Rezaee, Alireza Shalviri, Farnaz Shavandi, Reyhane Alidousti Shahraki, Mohammad Mahdavi, Mahshid Malakootian

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric rheumatology online journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zahra AmirsardariCardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
Mohammadmahdi AbbasiDepartment of General Surgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Shana AhadiSchool of Medicine, Jondishapour University of Medical Sciences, Ahvaz, Iran.
Aida RezaeeSchool of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Alireza ShalviriRazi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Farnaz ShavandiStudent Research Committee, Hamedan University of Medical Sciences, Hamedan, Iran.
Reyhane Alidousti ShahrakiTarbiat Modares University, Tehran, Iran.
Mohammad MahdaviCongenital Heart Disease Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
Mahshid MalakootianCardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran. m.malakootian@rhi.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious research has identified the significant roles of non-coding RNAs (ncRNAs) in Kawasaki disease (KD). This systematic review aims to elucidate the involvement and significance of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the pathogenesis and progression of KD. STUDY

designA systematic search was conducted across four databases (PubMed, Embase, Scopus, and Web of Science) up to June 19, 2023, without year restrictions. The risk of bias was assessed using the Newcastle-Ottawa Scale.

resultsThis review included 9 studies encompassing a total of 1894 individuals diagnosed with KD. Seven lncRNAs-Slco4a1, SOCS2-AS1, SRA, HCG22, MHRT, XLOC_006277, and HSD11B1-AS1-were found to be associated with KD, including polymorphisms such as lncRNA rs1814343 C > T and AC008392.1 rs7248320. Additionally, four circRNAs-circRNA-3302, circ7632, circANRIL, and hsa_circ_0123996-were associated with KD.

conclusionsBoth linear lncRNAs and circRNAs play critical roles in unraveling the mechanisms underlying KD, contributing to biomarker identification and potential therapeutic advances.

Indexed as

Mucocutaneous Lymph Node SyndromeRNA, CircularRNA, Long NoncodingHumansRNA, CircularRNA, Long NoncodingCircular RNAKawasaki diseaseLong non-coding RNANon-coding RNASystematic review

Identifiers

PMID40514733
PMCPMC12164146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.