Evidence map›Paper›PMID 40514683›Full record

ArticleCritical care (London, England)2025

Real-time changes in pulse pressure during a 10-second end-expiratory occlusion test reliably detect preload responsiveness.

Francesco Gavelli, Nello De Vita, Christopher Lai, Danila Azzolina, Arthur Pavot, Mathieu Jozwiak, Rui Shi, Imane Adda, Alexandra Beurton, Jean-Louis Teboul and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Francesco GavelliService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France. francesco.gavelli@uniupo.it.
Nello De VitaService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Christopher LaiService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Danila AzzolinaDepartment of Environmental and Preventive Science, University of Ferrara, Ferrara, Italy.
Arthur PavotService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Mathieu JozwiakService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Rui ShiService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Imane AddaService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Alexandra BeurtonService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Jean-Louis TeboulService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.
Xavier MonnetService de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Université Paris-Saclay, AP-HP, Inserm UMR S_999, FHU SEPSIS, CARMAS, Le Kremlin-Bicêtre, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe end-expiratory occlusion (EEO) test detects preload responsiveness through changes in cardiac index (ΔCI) during a 15-second respiratory hold at end-expiration. We investigated the diagnostic accuracy of EEO-induced changes in arterial pulse pressure (∆PP), especially when the duration of EEO is reduced to 10'' and 5'', and whether adding an end-inspiratory occlusion (EIO) improves this diagnostic accuracy.

methodsIn 143 mechanically ventilated patients with sinus rhythm, EEO and EIO were performed while recording ΔCI and ∆PP values. Either a fluid bolus-induced ΔCI ≥ 15% or a passive leg raising-induced ΔCI ≥ 10% defined preload responsiveness. The effects of the EEO and EIO tests on PP and CI were evaluated as the percentage difference between values averaged either over the last five seconds of the 15-sec respiratory holds (ΔPP

resultsSixty-one (43%) patients were preload responders. Both ∆CI

conclusionIn ventilated patients with sinus rhythm, real-time changes in PP during a 10-second EEO reliably detect preload responsiveness.

trial registrationNo. IDRCB 2010A0095942. Registered 04 January 2010.

Indexed as

Blood PressureExhalationAgedCardiac OutputFemaleHumansMaleMiddle AgedRespiration, ArtificialTime FactorsCardiac outputFluid challengeFluid responsivenessHaemodynamic monitoringPassive leg Raising

Identifiers

PMID40514683
PMCPMC12166565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.