Evidence map›Paper›PMID 40514678›Full record

ReviewLipids in health and disease2025

Lipid droplet accumulation in microglia and their potential roles.

Yunxia Li, Qi Zhao, Yan Wang, Wenyi Du, Riyun Yang, Jian Wu, Yi Li

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yunxia LiDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
Qi ZhaoDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
Yan WangDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
Wenyi DuDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
Riyun YangDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
Jian WuDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China. wujian@ntu.edu.cn.
Yi LiDepartment of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China. ly1203@ntu.edu.cn.

Funding

National Natural Science Foundation of China 82101455
6 · The paper itself

Abstract

Microglia are the resident immune cells of the central nervous system (CNS), where lipid metabolism is critical for maintaining homeostasis. In response to various external stimuli, they demonstrate a range of phenotypic expressions and lipid metabolic reprogramming. Lipid droplets (LDs) are dynamic organelles that function beyond energy storage, actively participating in neuropathological progress. Recent investigations have identified a subset of microglia characterized by the accumulation of LDs, referred to as "lipid-droplet-accumulating microglia" (LDAM). This review aims to investigate the processes involved in LD formation and degradation, the factors that modulate them, focusing particularly on the function of LDAM and their implications for CNS disorders. By synthesizing current evidence, we clarify the biological significance of LDs in these cells and their therapeutic targeting potential, providing new directions for future research.

Indexed as

Lipid DropletsLipid MetabolismMicrogliaAnimalsCentral Nervous SystemHumansCentral nervous systemLipid dropletsLipid metabolismMicrogliaNeurological disorders

Identifiers

PMID40514678
PMCPMC12166618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.