ArticlePharmaceutical research2025
Advancing Pharmaceutical Security: Noninvasive Detection of Falsified Vaccines and Drugs Using wNMR.
Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo develop and apply noninvasive analytical technologies to detect falsified vaccines and drugs.
methodsUnivariate and multivariate methods, based on the water nuclear magnetic resonance (wNMR) technology, was explored as a tool for noninvasive detection of simple and sophisticated falsified vaccines, biotherapeutics and anesthetics. All wNMR measurements were done noninvasively on sealed vials, prefilled syringes, and injection pens. Saline USP served as a simple falsified drug product while highly similar vaccines and drugs (brand vs. generics/biosimilars) served as each other's sophisticated falsified drug products for technology development and testing.
resultsSimple falsified drug products, represented by USP saline, can be differentiated from authentic vaccines and drugs by univariate wNMR. Sophisticated falsified drug products, represented by highly similar products, can be differentiated from authentic ones by univariate wNMR in some cases and by multivariate wNMR in all cases, attesting to the high discriminating power of wNMR in product authentication. The multivariate methods generate 2D and 3D data arrays that may serve as fingerprints of vaccines and drugs.
conclusionsA suite of noninvasive analytical methods, based on the wNMR technology, have been developed to detect falsified vaccines and drugs. wNMR analyzes vaccines and drugs in their primary containers without opening and uses benchtop instruments with no wet lab operations and no reagents. wNMR detection of falsified drug products may be implemented in low-resource settings for enhanced pharmaceutical security and preventive pharmacovigilance.
Indexed as
Identifiers
40514616What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.