Evidence map›Paper›PMID 40514576›Full record

Observational studyClinical and experimental medicine2025

Impact of age on frailty in liver cirrhosis: a prospective cohort study.

Omkolsoum Alhaddad, Maha Elsabaawy, Asmaa Abedelhai, Gamal Badra, Marwa Elfayoumy

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Omkolsoum AlhaddadDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt.
Maha ElsabaawyDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt. maha.ahmed@liver.menofia.edu.eg.ORCID http://orcid.org/0000-0002-3110-1547
Asmaa AbedelhaiDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt.
Gamal BadraDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt.
Marwa ElfayoumyDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty is an emerging predictor of adverse outcomes in liver cirrhosis, yet the interplay between aging and liver disease severity in driving frailty remains insufficiently understood. To evaluate the impact of age on the prevalence, severity, and predictors of frailty in patients with liver cirrhosis. In this prospective observational study, 460 adults with liver cirrhosis were assessed for frailty using the CFS (Clinical Frailty Scale) (CFS). Patients were classified as frail (CFS > 4) (210 cases), or non-frail (CFS ≤ 4) (250 cases). Demographic, clinical, and biochemical data of frail cases were collected. Multivariate and logistic regression analyses were performed to identify independent predictors of frailty. Frailty prevalence increased markedly with age-from 42% in patients aged 50-59 to over 90% in those aged ≥ 70. Age was moderately correlated with frailty (r = 0.40, p < 0.001). In multivariate analysis, both age (β = 0.0636, p < 0.001) and Child-Pugh score (β = 0.7874, p < 0.001) were independent predictors of frailty. Logistic regression (including interaction terms where appropriate) confirmed that each additional year of age increased frailty risk (OR = 1.13; 95% CI: 1.09-1.17, p < 0.001). Frailty in cirrhosis is strongly age-associated but also driven by hepatic dysfunction. These findings highlight the inadequacy of MELD-Na scores alone in capturing patient vulnerability, particularly in older adults. Future longitudinal studies and targeted prehabilitation strategies are warranted to mitigate frailty and improve outcomes in this vulnerable population.

Indexed as

FrailtyLiver CirrhosisAdultAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedPrevalenceProspective StudiesRisk FactorsSeverity of Illness IndexAgingChild–Pugh scoreFrailtyLiver cirrhosisSarcopenia

Identifiers

PMID40514576
PMCPMC12166003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.