Evidence map›Paper›PMID 40514452›Full record

ArticleCellular and molecular life sciences : CMLS2025

CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models.

Ilaria Musante, Davide Cangelosi, Lorenzo Muzzi, Fanny Jaudon, Marco Di Duca, Sara Guerrisi, Francesca Antonini, Yeraldin Chiquinquira Castillo De Spelorzi, Lorenzo A Cingolani, Federico Zara and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilaria MusanteMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Davide CangelosiClinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Lorenzo MuzziDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Fanny JaudonDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Marco Di DucaMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Sara GuerrisiMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Francesca AntoniniCore Facilities for Omics Science, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Yeraldin Chiquinquira Castillo De SpelorziGenomics Facility, Italian Institute of Technology (IIT), Genoa, Italy.
Lorenzo A CingolaniDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Federico ZaraMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy. federico.zara@unige.it.
Paolo ScudieriMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy. paolo.scudieri@unige.it.ORCID http://orcid.org/0000-0002-8112-4800

Funding

Fondazione Telethon GGP19181Fondazione Telethon GJC22053AMinistero dell'Istruzione, dell'Università e della Ricerca MNESYS
6 · The paper itself

Abstract

CACNA1A encodes the pore-forming α

Indexed as

Calcium Channels, N-TypeInduced Pluripotent Stem CellsLoss of Function MutationNeurogenesisCalcium ChannelsCell DifferentiationCells, CulturedHumansMutationNeuronsProtein IsoformsCACNA1A protein, humanCalcium ChannelsCalcium Channels, N-TypeProtein IsoformsHD-MEAInduced pluripotent stem cellsIn vitro modelsNeurodevelopmental diseasesScRNA-seq

Identifiers

PMID40514452
PMCPMC12165946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.