ReviewCommunications biology2025
Sperm navigation in humans: a concerted action of multiple means.
Review in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Single-cell metabolic profiling of stallion spermatozoa by flow cytometry using NADH and FAD autofluorescence†.Biology of reproduction · 2026Article
- The systems that transport ions and their impact on sperm function and male fertility.Function (Oxford, England) · 2026Review
- Simulated microgravity alters sperm navigation, fertilization and embryo development in mammals.Communications biology · 2026Article
- A framework for evaluating predicted sperm trajectories in crowded microscopy videos.PLoS computational biology · 2026Article
- Let the female tract choose: finding the sperm to enhanceAnimal reproduction · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For fertilization to occur in mammals, sperm cells must travel a long way through the female genital tract, overcoming numerous obstacles to reach the egg. In recent years it became clear that sperm arrival at the egg is not coincidental but rather that sperm cells must be guided, challenging long-standing beliefs. Three navigation means have been discovered: two active and highly sensitive means-chemotaxis and thermotaxis-and one passive means, rheotaxis. This review critically examines and puts into perspective the data accumulated over the past two decades about these navigation means and their underlying mechanisms. It questions whether these multiple navigation means are redundant or complementary, demonstrates how they work in harmony, and surveys successful attempts to harness them for improving artificial fertilization outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.