Evidence map›Paper›PMID 40514266›Full record

ArticleUltrasound in medicine & biology2025

Three-Dimensional Tissue Strain Measurement Using a Row-Column Array During Biaxial Testing of Excised Ventricular Porcine Myocardium.

Xavier Navy, Zhiyu Sheng, Kang Kim, John M Cormack

Abstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xavier NavyDepartment of Electrical Technology, Houston Community College, Houston, TX, USA.
Zhiyu ShengDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Vascular Medicine Institute, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Kang KimDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Vascular Medicine Institute, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
John M CormackDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Vascular Medicine Institute, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: j.m.n.cormack@gmail.com.

Funding

VMI Undergraduate Experience Program (VUE) R25HL130600 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jesus Tejero Bravo · 2016 to 2026
$1.1M
NHLBI NIH HHS R25 HL130600
6 · The paper itself

Abstract

objectiveTo implement and validate a 3D volume imaging sequence and 3D strain estimation procedure for enhanced biaxial mechanical testing of excised ventricular myocardium.

methodsOne specimen of right and one of left ventricular excised porcine myocardium were tested using dual-loading protocol quasistatic biaxial mechanical testing. During biaxial testing, volume ultrasound (US) images were acquired using a row-column addressed array probe using a synthetic aperture imaging sequence. Volume US images were used to compute tissue deformation using 3D correlation-based US speckle tracking. US-derived tissue strains were validated against repeated measurements using conventional optical camera imaging of the specimen surface deformation.

resultsSpeckle tracking yielded high-fidelity maps of tissue deformation in 3D throughout the entire sample volume. US-derived tissue strain is in good agreement with ground-truth camera-derived surface strain measurements (root mean square error is 1.6% strain).

conclusionThe 3D full-thickness strain measurement with US imaging is accurate and can enhance biomechanical insights from biaxial experimentation, especially in large tissues such as porcine and human myocardium where assumptions of plane stress and incompressibility may not apply.

Indexed as

Echocardiography, Three-DimensionalHeart VentriclesImaging, Three-DimensionalMechanical TestsAnimalsBiomechanical PhenomenaReproducibility of ResultsStress, MechanicalSwine

Identifiers

PMID40514266
PMCPMC13231444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.