Evidence map›Paper›PMID 40514220›Full record

ArticleBMJ global health2025

Time to inclusion of selected medicines for priority diseases in National Essential Medicines Lists compared with the WHO Model List.

Moska Hellamand, Tessa E Moleman, Annet P Post, Aukje K Mantel-Teeuwisse, Fatima Suleman, Hendrika A van den Ham

Abstract readComparative Study
In one paragraph

Article in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Moska HellamandUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.ORCID http://orcid.org/0009-0009-1799-7795
Tessa E MolemanUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Annet P PostUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Aukje K Mantel-TeeuwisseUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.ORCID http://orcid.org/0000-0002-8782-0698
Fatima SulemanWHO Collaborating Centre for Pharmaceutical Policy and Evidence Based Practice, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.ORCID http://orcid.org/0000-0002-8559-9168
Hendrika A van den HamUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands H.A.vandenHam@uu.nl.ORCID http://orcid.org/0000-0003-1339-9818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe WHO maintains a Model List of Essential Medicines, which guides countries in developing their National Essential Medicines List (NEML) to improve access to medicines. We aimed to assess the time it took for countries to adjust their NEMLs when medicines were added or deleted from the WHO Model List and if this differed between priority diseases.

methodsWe extracted medicines added or deleted from the WHO Model List (2007-2021) for selected priority diseases: diabetes, hepatitis C, HIV, oncology and tuberculosis. These medicines were compared with NEMLs from 20 countries; reimbursement lists (RLs) were used in the absence of an NEML. The time to inclusion in NEMLs/RLs and the percentage of included medicines in the most recent NEML/RL were assessed.

results90 medicines were added, and 15 medicines were deleted from the WHO Model List. Low-income and middle-income countries (LMICs) mostly included medicines in NEMLs after their addition to the WHO Model List (median: 1 year), and high-income countries prior to addition (median: -9 years). Medicines for HIV (62%) and tuberculosis (59%) were most frequently included in the most recent NEML/RL. High-income countries included the most medicines for diabetes (86%) and oncology (67%).

conclusionsThe WHO Model List may be a guiding tool for selecting medicines in LMICs, although it is applied differently between the priority diseases included in the present study. More medicines could be included in NEMLs for non-communicable diseases, which impose a large health burden on LMICs, as a first step to ensure their sustainable access.

Indexed as

Drugs, EssentialHealth PrioritiesHealth Services AccessibilityDeveloping CountriesDiabetes MellitusHIV InfectionsHumansTime FactorsTuberculosisWorld Health OrganizationDrugs, EssentialCancerDiabetesHIVTuberculosisViral hepatitis

Identifiers

PMID40514220
PMCPMC12164646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.