Evidence map›Paper›PMID 40514120›Full record

ArticleJACC. Case reports2025

A Case of Complete Functional Myocardial Regeneration in a Human Neonate.

Jyoti Gur, Rajiv Devanagondi, Rebecca Pratt, Frank Smith, Jason Mandell, Susan Martin, George A Porter

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jyoti GurDepartment of Pediatrics, Division of Pediatric Cardiology, University of Rochester, Rochester, New York, USA.
Rajiv DevanagondiDepartment of Pediatrics, Division of Pediatric Cardiology, University of Rochester, Rochester, New York, USA.
Rebecca PrattDepartment of Pediatrics, Division of Pediatric Cardiology, University of Rochester, Rochester, New York, USA; Department of Pediatrics, Division of Pediatric Cardiology, University of Buffalo, Buffalo, New York, USA.
Frank SmithDepartment of Pediatrics, Division of Pediatric Cardiology, University of Rochester, Rochester, New York, USA; Division of Pediatric Cardiology, SUNY Upstate Medical University, Syracuse, New York, USA.
Jason MandellDepartment of Pediatrics, Division of Pediatric Cardiology, University of Rochester, Rochester, New York, USA.
Susan MartinDepartment of Pediatrics, Division of Critical Care, University of Rochester, Rochester, New York, USA.
George A PorterDepartment of Pediatrics, Division of Pediatric Cardiology, University of Rochester, Rochester, New York, USA. Electronic address: george_porter@urmc.rochester.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple studies demonstrate the cardiac regenerative capacity in neonatal mice in the first week of life. Although a similar regenerative window in the human neonatal hearts has not been defined clearly, existing evidence supports the concept of human neonatal cardiac regeneration. CASE SUMMARY: A neonate with a complex form of cyanotic tetralogy of Fallot demonstrated complete recovery of left ventricular function after an acute cardiac injury suffered on day of life 8. DISCUSSION: This case report adds to limited but intriguing observations that human neonatal hearts may possess the regenerative capacity observed in animal models and that that capacity may be prolonged by hypoxemia. TAKE-HOME MESSAGES: A human neonatal heart has shown complete functional recovery after an ischemic injury. Hypoxemia may have extended the regenerative window of the human neonatal myocardium.

Indexed as

cardiac regenerationcongenital heart diseasehypoxemiaischemia

Identifiers

PMID40514120
PMCPMC12237733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.