ArticleJACC. Case reports2025
Reversed Remodeling Unveils Mitral Annular Disjunction.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Mitral Annular Disjunction: Form, Force, and Function.JACC. Case reports · 2026Article
- Short-Term Cardiac Effects of Bariatric Surgery: Is Weight Loss Alone Sufficient in Metabolically Healthy Morbidly Obese Patients?Journal of cardiovascular development and disease · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundMitral annular disjunction (MAD) is a structural abnormality increasingly recognized in association with mitral valve prolapse (MVP) and cardiomyopathy. Its clinical significance in nonischemic cardiomyopathy (NICM) is less understood. CASE SUMMARY: A 60-year-old man with NICM presented with progressive dyspnea and atrial fibrillation. Initial cardiac magnetic resonance imaging (CMR) showed severe left ventricular (LV) dilation, reduced ejection fraction (16%), and mild MVP without MAD. After 18 months of guideline-directed medical therapy, LV function normalized, but severe mitral regurgitation and significant MAD became more apparent. Surgical repair with a quadrangular resection and annuloplasty was successful, resolving symptoms. DISCUSSION: This case highlights the role of CMR in identifying MAD in NICM, and demonstrates how reverse LV remodeling can unmask MAD and MVP. Reduced tethering forces on mitral chordae after LV size reduction likely contributed to revealing the underlying pathology of bi-leaflet redundancy and prolapse.
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