Evidence map›Paper›PMID 40513842›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2025

In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness.

Jillian M Poska, Clarissa Wormsbaecher, Brittney M Cumbia, Madeline R Price, Marcos Cortes-Medina, Jacob Holter, Shashwat Agarwal, Xiaokui Molly Mo, Jonathan W Song, Craig J Burd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Rethinking the microenvironment's role in chemical-induced malignancy.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jillian M PoskaDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Clarissa WormsbaecherDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Brittney M CumbiaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Madeline R PriceDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA.
Marcos Cortes-MedinaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Jacob HolterDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Shashwat AgarwalDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.
Xiaokui Molly MoDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA; Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Jonathan W SongThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Craig J BurdDepartment of Molecular Genetics, The Ohio State University, 920 Biomedical Research Tower, 460 W. 12th Ave., Columbus, OH 43210, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. Electronic address: craig.burd@osumc.edu.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Defining the role of in utero estrogenic endocrine disruption on mammary gland stiffness and breast cancer riskR01ES032026 · NIEHS · OHIO STATE UNIVERSITY · PI BURD, CRAIG J · 2021 to 2025
$1.7M
NCI NIH HHS P30 CA016058NIEHS NIH HHS R01 ES032026NIEHS NIH HHS RO1 ES032026
6 · The paper itself

Abstract

In utero exposures to estrogenic endocrine disrupting compounds (EDCs) can increase breast cancer risk in adulthood. It has previously been shown that the estrogenic plasticizer bisphenol A (BPA) alters development of the mammary gland and increases both mammary gland stiffness and tumor susceptibility in rodent models following in utero exposure. Because of its endocrine disrupting properties, BPA has been substituted with structural analogues with varying abilities to activate estrogen receptor alpha (ERα). However, the impact of in utero exposure to many of these analogues is unknown. In the present study, we aimed to analyze the impact of bisphenol analogues on collagen deposition and mammary gland stiffness and characterize mammary epithelial development following exposure to these compounds. With the exception of bisphenol S, all analogues significantly increased mammary gland stiffness at a 25 µg/kg body weight dose in a manner that correlated to estrogenic activity. In contrast, significant effects on epithelial development endpoints were limited and did not follow a clear pattern. These results add to the growing literature on the hazard of bisphenol analogues and support the idea that these compounds promote abnormal mammary gland development. Furthermore, these data support a model that bisphenol compounds induce a microenvironment that may promote breast cancer development in an estrogen-dependent manner.

Indexed as

Benzhydryl CompoundsEndocrine DisruptorsMammary Glands, AnimalPhenolsAnimalsBisphenol A CompoundsBisphenol S CompoundsCollagenFemalePregnancyPrenatal Exposure Delayed EffectsSulfonesBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol SBisphenol S CompoundsCollagenEndocrine DisruptorsPhenolsSulfonesBisphenol analoguesEndocrine disruptionEstrogen receptor alphaIn utero exposureMammary glandTissue stiffness

Identifiers

PMID40513842
PMCPMC13535969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.