Evidence map›Paper›PMID 40513825›Full record

ArticleThe Canadian journal of cardiology2025

Frailty Risk After a Cardiovascular Event Among Community-Dwelling Older People: Influence of Sociodemographic, Polypharmacy, and Pre-event Frailty.

Aung Zaw Zaw Phyo, Andrew Tonkin, Sara E Espinoza, A R M Saifuddin Ekram, Robyn L Woods, Joanne Ryan

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aung Zaw Zaw PhyoSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address: aungzawzaw.phyo@monash.edu.
Andrew TonkinSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Sara E EspinozaCenter for Translational Geroscience, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
A R M Saifuddin EkramSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Funding

Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MURRAY, ANNE M · 2019 to 2023
$42.9M
NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

backgroundFrailty is a significant concern for older adults and can increase after a major health event. This study examined the risk of incident frailty after a cardiovascular disease (CVD) event among community-dwelling older people aged  ≥  65 years and explored whether sociodemographic factors, polypharmacy, and pre-event frailty influence their risk of developing frailty after a CVD event.

methodsThis study included a cohort of 738 participants (38.5% women) from the ASPREE study who were not classified as frail before their CVD event. Frailty was measured annually using the 64-item deficit-accumulation frailty index.

resultsOver an average 2.6 years after a CVD event, 333 individuals had incident frailty. In logistic regression models, increased chronological age, being a woman, and having polypharmacy were associated with 4% to 83% increased odds of developing frailty after a CVD event. Individuals with CVD residing in the inner regional area had about 50% higher odds of having frailty than those living in cities. This association was more evident among stroke survivors, with both inner regional (adjusted odds ratio [OR] 2.13) and outer regional or remote residents (adjusted OR 2.37) having greater odds of frailty. Individuals who were classified as pre-frail before their CVD event, had notably higher odds of progressing to frailty after the CVD event (adjusted OR 3.41).

conclusionsOur community-based study provides robust evidence that individuals who were women, older, pre-frail, with polypharmacy, and living in regional or remote areas have a markedly greater odds of developing frailty after a CVD event.

Indexed as

Cardiovascular DiseasesFrail ElderlyFrailtyIndependent LivingPolypharmacyAgedAged, 80 and overFemaleGeriatric AssessmentHumansIncidenceMaleRisk AssessmentRisk FactorsSociodemographic Factorscardiovascular diseasecommunity-dwelling older peoplefrailty riskpolypharmacysociodemographic

Identifiers

PMID40513825
PMCPMC13221273

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.