ArticleJournal of advanced research2026
SAE1 emerges as a pan-cancer driver and key regulator of HCC metastasis.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Hepatocellular carcinoma metastasis-immune microenvironment crosstalk: emerging mechanisms and immunotherapy.Cellular & molecular biology letters · 2026Review
- METTL3-mediated mMolecular cancer · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDysregulation of SUMOylation is implicated in cancer progression. While the role of SUMO-activating enzyme (SAE) and its mechanisms in cancer remain unclear.
objectivesWe investigated the role of SAE subunit 1 (SAE1) in hepatocellular carcinoma (HCC) metastasis.
methodsWe analyzed SAE1 expression across 28 pan-cancer subtypes. SAE1 complexes were identified and characterized using interactome analysis, Co-IP, immunofluorescence, and AlphaFold3 predictions. These findings were validated using in situ and vein tail injection xenograft mouse models, HCC organoids, and IHC using HCC tissue samples.
resultsIncreased SAE1 expression was correlated with poorer prognosis and higher driver gene mutation frequencies in six pan-cancers, particularly HCC. We identified a novel interaction between SAE1 and yin-yang 1 (YY1), where SAE1 enhances YY1 stability and activity, leading to Wnt3a transcription and subsequent activation of the Wnt pathway, eventually promoting cell migration and invasion. Moreover, a positive correlation between SAE1 and Wnt3a expression was confirmed in HCC organoids and HCC tissue samples.
conclusionThis study established SAE1 as a novel independent prognostic biomarker in multiple cancers and identified its mechanistic role in HCC progression, suggesting its potential value for future translational research toward therapeutic development.
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