ReviewJournal of molecular biology2025
Insights into Noncanonical and Diversified Functions of ABCF1: From Health to Disease.
Review in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exercise modulation of the alternative splicing landscape in human tissues.bioRxiv : the preprint server for biology · 2026Article
- NTRK2 promotes malignant progression and paclitaxel resistance of lung adenocarcinoma through targeting MYC/ABCF1 axis.Translational oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The ATP-binding cassette (ABC) family is one of the largest and most ancient classes of transporters found in nearly all living organisms. However, ABCF1 lacks a transmembrane domain and therefore does not function as a transporter. Recent studies point to an unexpectedly diverse role of ABCF1 in regulating cell-essential processes from mRNA translation, innate immune response, and phagocytosis in somatic cells, to transcriptional regulation in embryonic stem cells. ABCF1's functional plasticity is in part mediated by its disordered low-complexity domain (LCD) to enable dynamic biomolecular interactions. In this review, we discuss how ABCF1 takes advantage of the LCD to expand its functional repertoire and highlight fundamental principles of biomolecular assembly driving biological reactions. We also discuss the functions and mechanisms of ABCF1 in development and tissue homeostasis, and how dysregulation of ABCF1 contributes to diseases such as inflammatory disease and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.