Observational studyJournal of critical care2025
Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study.
Observational study in Journal of critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05287204 (Critical Illness Myopathy and Trajectory of Recovery in Acute Kidney Injury), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Critical Illness Myopathy and Trajectory of Recovery in Acute Kidney Injury (AKI) Requiring Continuous Renal Replacement Therapy (CRRT): A Prospective Observational Trial
Who cites it
8 citing papers in PubMed.
- Nutritional support in acute kidney injury requiring continuous renal replacement therapy: from metabolic alterations to clinical recommendations.International urology and nephrology · 2026Review
- Assessing the reliability of interprofessional raters on peripheral muscle ultrasonography in pediatric oncology: A prospective observational study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Observational
- Ultrasound assessment of muscle atrophy and its association with functional outcomes in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2026Review
- Metabolomic assessment reveals depletion of amino acids and energy metabolites in skeletal muscle after ischemic acute kidney injury in mice.Scientific reports · 2026Article
- Implementation and Challenges of Early-Phase Physiotherapy During Cardiovascular Intensive Care.Circulation reports · 2026Review
- Fluid removal improves muscle performance and weakness in critically ill patients: a pilot study.Intensive care medicine experimental · 2025Article
- Ultrasound-based assessment of muscle mass is associated with early recovery after kidney transplant: a prospective single-center study.BMC anesthesiology · 2025Article
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
purposeAcute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT) has been hypothesized to increase the risk of developing intensive care unit-associated weakness (ICU-AW), but prospective data are lacking. MATERIALS AND
methodsThis prospective observational study evaluated critically ill adults with AKI requiring CKRT at two U.S. academic hospitals. Using ultrasonography (US), we quantified changes in rectus femoris (RF) muscle mass and quality in the first week after CKRT initiation. At hospital discharge, we assessed for ICU-AW, physical function, and frailty.
resultsTwenty-three patients with median age 56 [IQR 47-60] years, BMI 29 [26-36] kg/m
conclusionsPatients with AKI requiring CKRT experienced significant muscle wasting in the first week following CKRT initiation and had high rate of ICU-AW at hospital discharge.
trial registrationNCT05287204, Registered 20 October 2021.
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Registered trials
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