ArticleOptics letters2025
High-resolution visible light OCT of the human retina with combined superluminescent diodes.
Article in Optics letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Visible Light Optical Coherence Tomography Reveals Aging at the Retinal Pigment Epithelium-Bruch's Membrane Interface.bioRxiv : the preprint server for biology · 2026Article
- The path to clinical translation for visible light optical coherence tomography in retinal imaging.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
High-resolution optical coherence tomography (OCT) requires broadband, spatially coherent light sources. Today, the source of choice for visible light OCT, the supercontinuum (SC), is bulky, expensive, and prone to excess noise. Here we demonstrate high-resolution visible light OCT of the human retina with a combined superluminescent diode (SLD) source. The source is longer in wavelength than the high blue light hazard range but shorter in wavelength than the high photopic efficiency range, ensuring subject safety and comfort. We report an axial resolution of 3.2 µm in the retina. We find that Bruch's membrane is well-delineated in subjects without ocular pathology, even though the axial resolution is ∼3× coarser than SC visible light OCT. Imaging of intermediate age-related macular degeneration is also shown. Within the cyan-green wavelength range of the SLD, optical density spectra resemble those of macular pigments. While the combined SLD approach does not achieve the micrometer-scale resolution of the SC, it potentially reduces the cost and complexity of visible light OCT while providing novel disease-relevant biomarkers, to the best of our knowledge, in human retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.